mortality/aging
• no homozygous pups are observed in litters; time of lethality is not specified
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Allele Symbol Allele Name Allele ID |
Htttm8Mem targeted mutation 8, Marcy E MacDonald MGI:3697907 |
Summary |
2 genotypes |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no homozygous pups are observed in litters; time of lethality is not specified
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|
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• some severely affected mutants die within 1 month of weaning
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• small throughout postnatal development and adulthood
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• mutants weigh significantly less at 1 week after birth and throughout adult life
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• develop a progressive movement disorder, with variable movement abnormalities evident from 2 months of age
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• first indications of movement abnormalities occur at around 2 months of age when mutants exhibit stiff tail and hindlimb clasping during tail suspension
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• over time, exhibit difficulties walking after handling
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• exhibit abnormal patterns of walking, including dragging hind limbs and a hopping gait that lacks normal alternating left-right steps
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• at the most advanced stages, most mutants become hypokinetic
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N |
• mutants do not exhibit the striatal pathology that is seen in Huntington Disease
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• mutants show a range of ventricle sizes, however, ventricle size is not correlated with the progressive movement disease as mutants with normal sized ventricles develop the disease and some asymptomatic mutants have enlarged ventricles
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• between 2 and 19 months of age, about 50% of mutants have enlarged lateral and third ventricles, extending from the anterior striatum to the level of the hippocampus
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• between 2 and 19 months of age, about 50% of mutants have enlarged lateral and third ventricles, extending from the anterior striatum to the level of the hippocampus
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• exhibit increased sensitivity to anesthesia-induced death, tolerating only 50-80% of the dose delivered to controls
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
NOT | Huntington's disease | DOID:12858 |
OMIM:143100 |
J:72915 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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