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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Drd3tm1Rmw
targeted mutation 1, R M Wightman
MGI:3698033
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Drd3tm1Rmw/Drd3tm1Rmw involves: 129P2/OlaHsd MGI:3699201
hm2
 		Drd3tm1Rmw/Drd3tm1Rmw involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J MGI:4429689


Genotype
MGI:3699201
hm1
Allelic
Composition		 Drd3tm1Rmw/Drd3tm1Rmw
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd3tm1Rmw mutation (0 available); any Drd3 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased stereotypic behavior ( J:117918 )
• stereotypy is greater (310 sec/30 minutes) than in wild-type (138 sec/30 minutes)

homeostasis/metabolism
decreased dopamine level ( J:117918 )
• striatal extracellular dopamine (DA) concentrations are 2-fold higher than wild-type; accumulation of L-DOPA is less than in striatal tissue in wild-type




Genotype
MGI:4429689
hm2
Allelic
Composition		 Drd3tm1Rmw/Drd3tm1Rmw
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd3tm1Rmw mutation (0 available); any Drd3 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:55027 )
N
• amphetamine-treated mice exhibit normal reductions in prepulse inhibition and startle reactivity

nervous system
nervous system phenotype ( J:55027 )
N
• amphetamine-treated mice exhibit normal reductions in prepulse inhibition and startle reactivity




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory