About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prkntm1Ykt
targeted mutation 1, Yasuko Kitao
MGI:3698054
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prkntm1Ykt/Prkntm1Ykt involves: 129P2/OlaHsd * C57BL/6 MGI:3699152
cx2
 		Prkntm1Ykt/Prkntm1Ykt
Tg(Prp-GPR37)1Ryot/0 		involves: 129P2/OlaHsd * C3H * C57BL/6 MGI:3814329
cx3
 		Prkntm1Ykt/Prkntm1Ykt
Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot 		involves: 129P2/OlaHsd * C3H * C57BL/6 MGI:3814331
cx4
 		Prkntm1Ykt/Prkntm1Ykt
Tg(PDGFB-GPR37)20Ryot/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3814328
cx5
 		Prkntm1Ykt/Prkntm1Ykt
Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot 		involves: 129P2/OlaHsd * C57BL/6 MGI:3814330


Genotype
MGI:3699152
hm1
Allelic
Composition		 Prkntm1Ykt/Prkntm1Ykt
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkntm1Ykt mutation (0 available); any Prkn mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal substantia nigra pars compacta morphology ( J:117737 )
• elevation of GPR37 levels by injection adeno-viral expression vectors results in increased dopaminergic neuronal cell death of cells in the substantia nigra pars compacta
• however, in untreated mice the number of dopaminergic neurons is similar to controls

growth/size/body
decreased body weight ( J:117737 )
• slight decrease in body weight

homeostasis/metabolism
increased dopamine level ( J:117737 )
• slight increase in striatal dopamine level




Genotype
MGI:3814329
cx2
Allelic
Composition		 Prkntm1Ykt/Prkntm1Ykt
Tg(Prp-GPR37)1Ryot/0
Genetic
Background		 involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkntm1Ykt mutation (0 available); any Prkn mutation (54 available)
Tg(Prp-GPR37)1Ryot mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased dopaminergic neuron number ( J:140326 )
• at 18 months of age, the number of dopamine transporter and VMAT2+ cells is decreased compared to in wild-type mice
neuron degeneration ( J:140326 )
• at 12 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

cellular
abnormal redox activity ( J:140326 )
• at 18 and 24 months, mice exhibit a 30% reduction in mitochondrial complex I activity compared to in wild type mice
oxidative stress ( J:140326 )
• mice exhibit an age-dependent increase in the levels of a marker of oxidative damage in the midbrain region
• however, mice do exhibit oxidative damage in the cortex region

behavior/neurological
behavior/neurological phenotype ( J:140326 )
N
• despite loss of dopaminergic neurons, mice exhibit normal behaviors

homeostasis/metabolism
decreased dopamine level ( J:140326 )
• by 24 months
increased dopamine level ( J:140326 )
• in young animals

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Parkinson's disease 2 DOID:0060368 OMIM:600116
 J:140326




Genotype
MGI:3814331
cx3
Allelic
Composition		 Prkntm1Ykt/Prkntm1Ykt
Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic
Background		 involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkntm1Ykt mutation (0 available); any Prkn mutation (54 available)
Tg(Prp-GPR37)1Ryot mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased dopaminergic neuron number ( J:140326 )
• at 12 months of age, the number of dopamine transporter and VMAT2+ cells is decreased compared to in wild-type mice
neuron degeneration ( J:140326 )
• at 6 months of age, mice exhibit a reduction in the number of TH+ neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis
• however, mice do not exhibit a change in hippocampal neurons at 24 months of age

cellular
abnormal redox activity ( J:140326 )
• at 18 and 24 months, mice exhibit a 30% reduction in mitochondrial complex I activity compared to in wild type mice

behavior/neurological
behavior/neurological phenotype ( J:140326 )
N
• despite loss of dopaminergic neurons, mice exhibit normal behaviors

homeostasis/metabolism
decreased dopamine level ( J:140326 )
• by 24 months
increased dopamine level ( J:140326 )
• in young animals

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Parkinson's disease 2 DOID:0060368 OMIM:600116
 J:140326




Genotype
MGI:3814328
cx4
Allelic
Composition		 Prkntm1Ykt/Prkntm1Ykt
Tg(PDGFB-GPR37)20Ryot/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkntm1Ykt mutation (0 available); any Prkn mutation (54 available)
Tg(PDGFB-GPR37)20Ryot mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
neuron degeneration ( J:140326 )
• at 18 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

behavior/neurological
behavior/neurological phenotype ( J:140326 )
N
• mice exhibit normal behaviors

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Parkinson's disease 2 DOID:0060368 OMIM:600116
 J:140326




Genotype
MGI:3814330
cx5
Allelic
Composition		 Prkntm1Ykt/Prkntm1Ykt
Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkntm1Ykt mutation (0 available); any Prkn mutation (54 available)
Tg(PDGFB-GPR37)20Ryot mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
neuron degeneration ( J:140326 )
• at 12 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

behavior/neurological
behavior/neurological phenotype ( J:140326 )
N
• mice exhibit normal behaviors

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Parkinson's disease 2 DOID:0060368 OMIM:600116
 J:140326




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory