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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fhl1tm1Chen
targeted mutation 1, Ju Chen
MGI:3698169
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Fhl1tm1Chen/Y
Tg(Myh6-Gnaq)25Gwd/0 		involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N MGI:3832664
ot2
 		Fhl1tm1Chen/Y involves: 129S1/Sv * 129X1/SvJ * Black Swiss MGI:3698532


Genotype
MGI:3832664
cx1
Allelic
Composition		 Fhl1tm1Chen/Y
Tg(Myh6-Gnaq)25Gwd/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhl1tm1Chen mutation (0 available); any Fhl1 mutation (9 available)
Tg(Myh6-Gnaq)25Gwd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:144736 )
N
• cardiomyopathy induced by the expression of the transgene is rescued




Genotype
MGI:3698532
ot2
Allelic
Composition		 Fhl1tm1Chen/Y
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhl1tm1Chen mutation (0 available); any Fhl1 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiovascular system physiology ( J:144736 )
• when subjected to 15% to 20% stretch, cardiac muscles exhibit reduced diastolic stress compared to wild-type muscle
• when stretched to a diastolic stress of 20 kPA, sarcomere length in cardiac muscles is increased compared to in wild-type muscle
• however, other active mechanical properties such as developed systolic stress, time to peak contraction, maximum rate of force production, 90% relaxation time, and maximum rate of force decline are normal
decreased response of heart to induced stress ( J:144736 )
• cardiac hypertrophy following transverse aortic constriction (TAC) is less than in wild-type mice with smaller left ventricular to body weight ratio, cardiomyocyte cross-sectional area, left ventricle posterior wall thickness, and interventricular septal wall thickness
• the percentage of left ventricle fractional shortening following TAC is similar to in sham-operated mice
• cardiac function following TAC is preserved unlike in similarly treated wild-type mice

homeostasis/metabolism
decreased response of heart to induced stress ( J:144736 )
• cardiac hypertrophy following transverse aortic constriction (TAC) is less than in wild-type mice with smaller left ventricular to body weight ratio, cardiomyocyte cross-sectional area, left ventricle posterior wall thickness, and interventricular septal wall thickness
• the percentage of left ventricle fractional shortening following TAC is similar to in sham-operated mice
• cardiac function following TAC is preserved unlike in similarly treated wild-type mice

behavior/neurological
behavior/neurological phenotype ( J:117793 )
N
• gross behavior is normal

nervous system
nervous system phenotype ( J:117793 )
N
• males exhibit normal brain weight and morphology

growth/size/body
growth/size/body region phenotype ( J:117793 )
N
• body weight is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory