Analysis Tools
cardiovascular system
 N |
• cardiomyopathy induced by the expression of the transgene is rescued
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Allele Symbol Allele Name Allele ID |
Fhl1tm1Chen targeted mutation 1, Ju Chen MGI:3698169 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• cardiomyopathy induced by the expression of the transgene is rescued
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when subjected to 15% to 20% stretch, cardiac muscles exhibit reduced diastolic stress compared to wild-type muscle
• when stretched to a diastolic stress of 20 kPA, sarcomere length in cardiac muscles is increased compared to in wild-type muscle
• however, other active mechanical properties such as developed systolic stress, time to peak contraction, maximum rate of force production, 90% relaxation time, and maximum rate of force decline are normal
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• cardiac hypertrophy following transverse aortic constriction (TAC) is less than in wild-type mice with smaller left ventricular to body weight ratio, cardiomyocyte cross-sectional area, left ventricle posterior wall thickness, and interventricular septal wall thickness
• the percentage of left ventricle fractional shortening following TAC is similar to in sham-operated mice
• cardiac function following TAC is preserved unlike in similarly treated wild-type mice
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• cardiac hypertrophy following transverse aortic constriction (TAC) is less than in wild-type mice with smaller left ventricular to body weight ratio, cardiomyocyte cross-sectional area, left ventricle posterior wall thickness, and interventricular septal wall thickness
• the percentage of left ventricle fractional shortening following TAC is similar to in sham-operated mice
• cardiac function following TAC is preserved unlike in similarly treated wild-type mice
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N |
• gross behavior is normal
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N |
• males exhibit normal brain weight and morphology
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N |
• body weight is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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