About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Thoc1tm2Dwg
targeted mutation 2, David W Goodrich
MGI:3698313
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Thoc1tm2Dwg/Thoc1tm2Dwg involves: 129S4/SvJae * C57BL/6J MGI:3698528
ht2
 		Thoc1tm1Dwg/Thoc1tm2Dwg involves: 129S4/SvJae * C57BL/6J MGI:3698530


Genotype
MGI:3698528
hm1
Allelic
Composition		 Thoc1tm2Dwg/Thoc1tm2Dwg
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thoc1tm2Dwg mutation (0 available); any Thoc1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
decreased embryo size ( J:117869 )
• small size is detectable as early as E12.5

growth/size/body
decreased embryo size ( J:117869 )
• small size is detectable as early as E12.5
decreased body size ( J:117869 )
• 100% penetrance; reduced size persists throughout adulthood
decreased body weight ( J:117869 )
• in adulthood, weight is about 80% of wild-type




Genotype
MGI:3698530
ht2
Allelic
Composition		 Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thoc1tm1Dwg mutation (0 available); any Thoc1 mutation (46 available)
Thoc1tm2Dwg mutation (0 available); any Thoc1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:117869 )
• embryos are detected at E13.5 but no viable neonates are recovered indicating lethality after E13.5 but before birth

embryo

growth/size/body
decreased embryo size ( J:117869 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory