Analysis Tools
immune system
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• mice infected with a sublethal dose of L. monocytogenes produce less IL6 and TNF at 3 h after infection but have higher cytokine levels at 24 and 48 h after infection
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• impaired production of cytokines associated with early innate immune responses
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• impaired production of IL6 and TNF in primary macrophages in response to stimulation with poly(I:C), loxoribine, peptidoglycan, or muramyl dipeptide
• however, production of IL6 and TNF in response to LPS or diacylated lipopeptide FSL-1 stimulation is similar to control cells
• macrophages infected with L. monocytogenes or vesicular stomatitis virus produce less IL6 and TNF compared to controls
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• mice infected with a sublethal dose of L. monocytogenes have higher bacterial burdens at 2, 4, and 9 days after infection with enlarged spleens and in severe cases signs of splenic necrosis at 9 days after infection
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homeostasis/metabolism
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• mice infected with a sublethal dose of L. monocytogenes produce less IL6 and TNF at 3 h after infection but have higher cytokine levels at 24 and 48 h after infection
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hematopoietic system
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• impaired production of IL6 and TNF in primary macrophages in response to stimulation with poly(I:C), loxoribine, peptidoglycan, or muramyl dipeptide
• however, production of IL6 and TNF in response to LPS or diacylated lipopeptide FSL-1 stimulation is similar to control cells
• macrophages infected with L. monocytogenes or vesicular stomatitis virus produce less IL6 and TNF compared to controls
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