Phenotypes associated with this allele

• Allele Symbol: Ryr2^{tm1(CAG-KRAS*G12V,-lacZ)Nobs}
• Allele Name: targeted mutation 1, Noboru Suzuki
• Allele ID: MGI:3698416
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ryr2^tm1(CAG-KRAS*G12V,-lacZ)Nobs/Ryr2^tm1(CAG-KRAS*G12V,-lacZ)Nobs Trp53^tm1Sia/Trp53^tm1Sia	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3698871
cx2	Ryr2^tm1(CAG-KRAS*G12V,-lacZ)Nobs/Ryr2^tm1(CAG-KRAS*G12V,-lacZ)Nobs Trp53^tm1Sia/Trp53^+	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3698873

Genotype
MGI:3698871

cn1

• Allelic Composition: Ryr2^{tm1(CAG-KRAS*G12V,-lacZ)Nobs}/Ryr2^{tm1(CAG-KRAS*G12V,-lacZ)Nobs}; Trp53^tm1Sia/Trp53^tm1Sia
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:117828 )

• within 10 weeks of electroporation of a cre expression vector into the muscles of the lower right leg, soft tissue tumors of the lower right leg develop in 100% of mice, while uninjected mice or injected Ryr2 homozygous, Trp53-sufficient mice (~wild-type) do not develop tumors even after 15 weeks

increased rhabdomyosarcoma incidence ( J:117828 )

• tumors are of this type

immune system

myositis ( J:117828 )

• 3 weeks after electroporation, mice show persistent accumulation of mononuclear cells and contain immature myocytes and proliferating cells, at site of electroporation, whereas controls do not

muscle

myositis ( J:117828 )

• 3 weeks after electroporation, mice show persistent accumulation of mononuclear cells and contain immature myocytes and proliferating cells, at site of electroporation, whereas controls do not

increased rhabdomyosarcoma incidence ( J:117828 )

• tumors are of this type

Genotype
MGI:3698873

cx2

• Allelic Composition: Ryr2^{tm1(CAG-KRAS*G12V,-lacZ)Nobs}/Ryr2^{tm1(CAG-KRAS*G12V,-lacZ)Nobs}; Trp53^tm1Sia/Trp53⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

neoplasm

increased tumor incidence ( J:117828 )

• within 10 weeks of electroporation of a cre expression vector into the muscles of the lower right leg, soft tissue tumors of the lower right leg develop in 40% of mice

increased rhabdomyosarcoma incidence ( J:117828 )

• tumors are of this type

muscle

increased rhabdomyosarcoma incidence ( J:117828 )

• tumors are of this type