Phenotypes associated with this allele

• Allele Symbol: Suds3^tm1Rdp
• Allele Name: targeted mutation 1, Ronald DePinho
• Allele ID: MGI:3698417
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Suds3^tm1Rdp/Suds3^tm1Rdp	involves: 129S6/SvEvTac	MGI:3698875

Genotype
MGI:3698875

cn1

• Allelic Composition: Suds3^tm1Rdp/Suds3^tm1Rdp
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal chromosome morphology ( J:86008 )

• chromomes from transfected cells display abnormal acetylation and methylation compared to wild-type cells

aneuploidy ( J:86008 )

• rampant aneuploidy occurs in transfected cells in culture

polyploidy ( J:86008 )

• transfected cells show an increase in polyploidy in culture; 30% of cells are polynucleated vs 11% of wild-type

abnormal cell cycle ( J:86008 )

• cultured MEFs (mouse embryonic fibroblasts) transfected with a cre retrovirus show dramatic growth arrest and dimished survival compared to wild-type of heterozygous MEFs