Phenotypes associated with this allele

• Allele Symbol: Suds3^tm1.1Rdp
• Allele Name: targeted mutation 1.1, Ronald DePinho
• Allele ID: MGI:3698418
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Suds3^tm1.1Rdp/Suds3^tm1.1Rdp	involves: 129S6/SvEvTac	MGI:3698874
ht2	Suds3^tm1.1Rdp/Suds3^+	involves: C57BL/6 * FVB	MGI:3698866
cx3	Suds3^tm1.1Rdp/Suds3^+ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6 * FVB	MGI:3698863
cx4	Suds3^tm1.1Rdp/Suds3^+ Trp53^tm1Tyj/Trp53^+	involves: 129S2/SvPas * C57BL/6 * FVB	MGI:3698864

Genotype
MGI:3698874

hm1

• Allelic Composition: Suds3^tm1.1Rdp/Suds3^tm1.1Rdp
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:86008 )

• homozygous embryos are not produced at E6.5 or later

Genotype
MGI:3698866

ht2

• Allelic Composition: Suds3^tm1.1Rdp/Suds3⁺
• Genetic Background: involves: C57BL/6 * FVB

normal phenotype

no abnormal phenotype detected ( J:117829 )

• heterozygotes have normal lifespans, normal organs, age-related physiology and tissue changes, and normal cancer incidence

Genotype
MGI:3698863

cx3

• Allelic Composition: Suds3^tm1.1Rdp/Suds3⁺; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB

cellular

aneuploidy ( J:117829 )

• tumor cells in primary cultures are typically aneuploid with chromosome counts of 30 to >100; tumors from controls are usually euploid

• tumor metaphases posess multi-radial chromosomes and sometimes more than 3 chromosomes are associated through their centromeric regions

neoplasm

increased tumor incidence ( J:117829 )

• compared to Suds3-sufficient Trp53-null mice, mice show increased tumor multiplicity per mouse (2.45 vs 1.2 macroscopic tumors)

decreased tumor latency ( J:117829 )

• compared to Suds3-sufficient Trp53-null mice, mice show accelerated tumor onset (latency of 12.3 vs 13.9 weeks)

Genotype
MGI:3698864

cx4

• Allelic Composition: Suds3^tm1.1Rdp/Suds3⁺; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB

neoplasm

decreased tumor incidence ( J:117829 )

• mice show a suppression of the cancer phenotype compared to Sds-haploinsufficinet, Trp53-null mice