Analysis Tools
growth/size/body
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• by 6-8 months of age, mutants gain 20% in body mass compared to wild-type littermates
• after 8 weeks on a high fat diet, mutants show increased body weight compared to controls
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homeostasis/metabolism
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• enzymatic markers of liver damage appear by 1 year of age
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• serum concentrations are elevated on standard diet at 8-12 weeks and increase with age
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• after 8 weeks on a high fat diet, hyperglycemia is exacerbated in mutants
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• insulin levels do not increase upon glucose challenge
• after 8 weeks on a high fat diet, hyperinsulinemia is moderately reduced
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• levels are below normal at 8-12 weeks on standard diet
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• in 8-12 week-old mice, levels are significantly elevated on standard diet
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• in 8-12 week-old mice, levels are significantly elevated on standard diet
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• mice show abnormal response in tolerance test, with glucose remaining persistently elevated
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• prevalent in mutants at 1 year of age
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cellular
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• uptake of a labeled analog is significantly reduced in mutant cells
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liver/biliary system
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• hepatic steatosis is pronounced at 6 months
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