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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxo1tm1.1Rdp
targeted mutation 1.1, Ronald DePinho
MGI:3698868
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Foxo1tm1.1Rdp/Foxo1tm1.1Rdp involves: 129S1/Sv * FVB/N MGI:3706811
cn2
 		Foxo1tm1Rdp/Foxo1tm1.1Rdp
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0 		involves: 129P2/OlaHsd * 129S1/Sv MGI:4430557
cn3
 		Foxo1tm1.1Rdp/Foxo1+
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0 		involves: 129P2/OlaHsd * 129S1/Sv MGI:4430558
cn4
 		Adipoqtm1Ish/Adipoqtm1Ish
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Tg(Col1a1-cre)1Kry/0 		involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:5520079
cn5
 		Foxo1tm1Rdp/Foxo1tm1.1Rdp
Tg(Col1a1-cre)1Kry/0 		involves: 129S1/Sv * FVB MGI:5520078
cn6
 		Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0 		involves: 129S4/SvJae * 129S6/SvEvTac MGI:5784501
cn7
 		Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Tg(CYP19A1-cre)1Jri/0 		involves: 129S6/SvEvTac MGI:5784494
cn8
 		Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Amhr2tm3(cre)Bhr/Amhr2+ 		involves: 129S6/SvEvTac * 129S7/SvEvBrd MGI:5784489


Genotype
MGI:3706811
hm1
Allelic
Composition		 Foxo1tm1.1Rdp/Foxo1tm1.1Rdp
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1.1Rdp mutation (0 available); any Foxo1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4430557
cn2
Allelic
Composition		 Foxo1tm1Rdp/Foxo1tm1.1Rdp
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1.1Rdp mutation (0 available); any Foxo1 mutation (32 available)
Foxo1tm1Rdp mutation (2 available); any Foxo1 mutation (32 available)
Igh-Jtm1Cgn mutation (3 available); any Igh-J mutation (13 available)
Ightm4Cgn mutation (0 available); any Igh mutation (44 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:157297 )
• mice exhibit an accumulation of IgM negative B cells compared to in Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice
• mice exhibit an efficient rescue of BCR negative B cells compared with Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice
• however, follicle B cells are rescued compared to in Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice

hematopoietic system
increased B cell number ( J:157297 )
• mice exhibit an accumulation of IgM negative B cells compared to in Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice
• mice exhibit an efficient rescue of BCR negative B cells compared with Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice
• however, follicle B cells are rescued compared to in Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice




Genotype
MGI:4430558
cn3
Allelic
Composition		 Foxo1tm1.1Rdp/Foxo1+
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1.1Rdp mutation (0 available); any Foxo1 mutation (32 available)
Igh-Jtm1Cgn mutation (3 available); any Igh-J mutation (13 available)
Ightm4Cgn mutation (0 available); any Igh mutation (44 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:157297 )
• mice exhibit a limited rescue of IgM negative B cells compared to in Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice

hematopoietic system
increased B cell number ( J:157297 )
• mice exhibit a limited rescue of IgM negative B cells compared to in Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice




Genotype
MGI:5520079
cn4
Allelic
Composition		 Adipoqtm1Ish/Adipoqtm1Ish
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoqtm1Ish mutation (0 available); any Adipoq mutation (40 available)
Foxo1tm1.1Rdp mutation (0 available); any Foxo1 mutation (32 available)
Foxo1tm1Rdp mutation (2 available); any Foxo1 mutation (32 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:199264 )
N
• mice exhibit normal body weight

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:199264 )
N
• mice exhibit normal osteocalcin serum levels

skeleton
skeleton phenotype ( J:199264 )
N
• mice exhibit normal bone mass and osteoblast numbers




Genotype
MGI:5520078
cn5
Allelic
Composition		 Foxo1tm1Rdp/Foxo1tm1.1Rdp
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: 129S1/Sv * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1.1Rdp mutation (0 available); any Foxo1 mutation (32 available)
Foxo1tm1Rdp mutation (2 available); any Foxo1 mutation (32 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:199264 )
N
• mice exhibit normal osteocalcin serum levels




Genotype
MGI:5784501
cn6
Allelic
Composition		 Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1.1Rdp mutation (0 available); any Foxo1 mutation (32 available)
Foxo1tm1Rdp mutation (2 available); any Foxo1 mutation (32 available)
Foxo3tm1.1Rdp mutation (1 available); any Foxo3 mutation (51 available)
Foxo3tm1Rdp mutation (1 available); any Foxo3 mutation (51 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased granulosa cell tumor incidence ( J:232961 )
• 60% incidence of granulosa cell tumor occurrence, with early tumor development
• granulosa cell tumors are either solid and surrounded by a thin layer of ovarian tissue containing a few growing follicles or are larger and contain tubular-like structures of different sizes and shapes surrounded by a basal lamina of collagen IV
• mice injected with superovulatory levels of equine gonadotropin and human gonadotropin at 6 weeks of age develop large granulosa cell tumors early

homeostasis/metabolism
abnormal circulating hormone level ( J:232961 )
• tumor bearing mice exhibit increased levels of serum inhibin A and inhibin B
suppressed circulating follicle stimulating hormone level ( J:232961 )
• serum follicle stimulating hormone levels are below the level of detection in tumor bearing mice
decreased circulating luteinizing hormone level ( J:232961 )
• serum luteinizing hormone levels are below the level of detection in tumor bearing mice

neoplasm
increased granulosa cell tumor incidence ( J:232961 )
• 60% incidence of granulosa cell tumor occurrence, with early tumor development
• granulosa cell tumors are either solid and surrounded by a thin layer of ovarian tissue containing a few growing follicles or are larger and contain tubular-like structures of different sizes and shapes surrounded by a basal lamina of collagen IV
• mice injected with superovulatory levels of equine gonadotropin and human gonadotropin at 6 weeks of age develop large granulosa cell tumors early

reproductive system
increased granulosa cell tumor incidence ( J:232961 )
• 60% incidence of granulosa cell tumor occurrence, with early tumor development
• granulosa cell tumors are either solid and surrounded by a thin layer of ovarian tissue containing a few growing follicles or are larger and contain tubular-like structures of different sizes and shapes surrounded by a basal lamina of collagen IV
• mice injected with superovulatory levels of equine gonadotropin and human gonadotropin at 6 weeks of age develop large granulosa cell tumors early




Genotype
MGI:5784494
cn7
Allelic
Composition		 Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Tg(CYP19A1-cre)1Jri/0
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1.1Rdp mutation (0 available); any Foxo1 mutation (32 available)
Foxo1tm1Rdp mutation (2 available); any Foxo1 mutation (32 available)
Foxo3tm1.1Rdp mutation (1 available); any Foxo3 mutation (51 available)
Foxo3tm1Rdp mutation (1 available); any Foxo3 mutation (51 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:232961 )
• 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin exhibit ovaries with many abnormal, degenerating follicles in which oocytes are shrunken or absent
abnormal granulosa cell morphology ( J:232961 )
• in some ovarian follicles of mice injected with superovulatory levels of equine gonadotropin and human gonadotropin, granulosa cells are abnormally displaced and growing on one side
increased granulosa cell tumor incidence ( J:232961 )
• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
• 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts

homeostasis/metabolism
abnormal circulating hormone level ( J:232961 )
• tumor bearing mice exhibit increased levels of serum inhibin A and inhibin B
increased circulating estradiol level ( J:232961 )
• serum levels of estradiol are elevated in tumor bearing mice
suppressed circulating follicle stimulating hormone level ( J:232961 )
• serum follicle stimulating hormone levels are below the level of detection in tumor bearing mice
decreased circulating luteinizing hormone level ( J:232961 )
• serum luteinizing hormone levels are below the level of detection in tumor bearing mice

neoplasm
increased granulosa cell tumor incidence ( J:232961 )
• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
• 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts

reproductive system
abnormal ovarian follicle morphology ( J:232961 )
• 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin exhibit ovaries with many abnormal, degenerating follicles in which oocytes are shrunken or absent
abnormal granulosa cell morphology ( J:232961 )
• in some ovarian follicles of mice injected with superovulatory levels of equine gonadotropin and human gonadotropin, granulosa cells are abnormally displaced and growing on one side
increased granulosa cell tumor incidence ( J:232961 )
• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
• 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
 J:232961




Genotype
MGI:5784489
cn8
Allelic
Composition		 Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Amhr2tm3(cre)Bhr/Amhr2+
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (29 available)
Foxo1tm1.1Rdp mutation (0 available); any Foxo1 mutation (32 available)
Foxo1tm1Rdp mutation (2 available); any Foxo1 mutation (32 available)
Foxo3tm1.1Rdp mutation (1 available); any Foxo3 mutation (51 available)
Foxo3tm1Rdp mutation (1 available); any Foxo3 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:232961 )
• ovaries of 3-4 month old mice contain many small abnormal follicles in which fragmented oocytes or only remnants of the zona pellucida are evident
• some follicles in 3-4 month old mice assume the appearance of testicular-like structures
increased granulosa cell tumor incidence ( J:232961 )
• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
ovary cyst ( J:232961 )
• ovaries of 3-4 month old mice typically contain large cyst-like structures, some of which are hemorrhagic

homeostasis/metabolism
abnormal circulating hormone level ( J:232961 )
• tumor bearing mice exhibit increased levels of serum inhibin A and inhibin B
increased circulating estradiol level ( J:232961 )
• serum levels of estradiol are elevated in tumor bearing mice
suppressed circulating follicle stimulating hormone level ( J:232961 )
• serum follicle stimulating hormone levels are below the level of detection in tumor bearing mice
decreased circulating luteinizing hormone level ( J:232961 )
• serum luteinizing hormone levels are below the level of detection in tumor bearing mice

neoplasm
increased granulosa cell tumor incidence ( J:232961 )
• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis

reproductive system
abnormal ovarian follicle morphology ( J:232961 )
• ovaries of 3-4 month old mice contain many small abnormal follicles in which fragmented oocytes or only remnants of the zona pellucida are evident
• some follicles in 3-4 month old mice assume the appearance of testicular-like structures
increased granulosa cell tumor incidence ( J:232961 )
• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
ovary cyst ( J:232961 )
• ovaries of 3-4 month old mice typically contain large cyst-like structures, some of which are hemorrhagic

growth/size/body
ovary cyst ( J:232961 )
• ovaries of 3-4 month old mice typically contain large cyst-like structures, some of which are hemorrhagic

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
 J:232961




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory