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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxo4tm1.1Rdp
targeted mutation 1.1, Ronald DePinho
MGI:3698870
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Foxo3tm1.1Rdp/Foxo3tm1.1Rdp
Foxo4tm1.1Rdp/Foxo4tm1.1Rdp 		involves: 129S1/Sv * 129S6/SvEvTac * FVB/N MGI:3706813
cx2
 		Foxo3tm1.1Rdp/Foxo3+
Foxo4tm1.1Rdp/Foxo4tm1.1Rdp 		involves: 129S1/Sv * 129S6/SvEvTac * FVB/N MGI:3706828


Genotype
MGI:3706813
cx1
Allelic
Composition		 Foxo3tm1.1Rdp/Foxo3tm1.1Rdp
Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo3tm1.1Rdp mutation (1 available); any Foxo3 mutation (51 available)
Foxo4tm1.1Rdp mutation (0 available); any Foxo4 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:118179 )
• other unclassified tumors are seen with higher frequencies (3/27 vs 0 wild-type)
increased pituitary adenoma incidence ( J:118179 )
• females show increased pituitary adenoma (6/13 vs 0 wild-type)
increased Harderian gland tumor incidence ( J:118179 )
• mice show increased incidence of Harderian gland tumors (4/27 vs 1/6 wild-type)
increased ovary tumor incidence ( J:118179 )
• slightly increased incidence of ovarian stromal neoplasms (1/13 vs o wild-type)
increased ovarian teratoma incidence ( J:118179 )
• increased incidence of cystic teratoma (ovary) compared to wild-type (2/13 vs 0 wild-type)
increased lung adenoma incidence ( J:118179 )
• increased incidence of lung tumors (7/27 mice vs 1/6 wild-type)

respiratory system
increased lung adenoma incidence ( J:118179 )
• increased incidence of lung tumors (7/27 mice vs 1/6 wild-type)

reproductive system
increased ovary tumor incidence ( J:118179 )
• slightly increased incidence of ovarian stromal neoplasms (1/13 vs o wild-type)
increased ovarian teratoma incidence ( J:118179 )
• increased incidence of cystic teratoma (ovary) compared to wild-type (2/13 vs 0 wild-type)

nervous system
increased pituitary adenoma incidence ( J:118179 )
• females show increased pituitary adenoma (6/13 vs 0 wild-type)

endocrine/exocrine glands
increased pituitary adenoma incidence ( J:118179 )
• females show increased pituitary adenoma (6/13 vs 0 wild-type)
increased Harderian gland tumor incidence ( J:118179 )
• mice show increased incidence of Harderian gland tumors (4/27 vs 1/6 wild-type)
increased ovary tumor incidence ( J:118179 )
• slightly increased incidence of ovarian stromal neoplasms (1/13 vs o wild-type)
increased ovarian teratoma incidence ( J:118179 )
• increased incidence of cystic teratoma (ovary) compared to wild-type (2/13 vs 0 wild-type)




Genotype
MGI:3706828
cx2
Allelic
Composition		 Foxo3tm1.1Rdp/Foxo3+
Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo3tm1.1Rdp mutation (1 available); any Foxo3 mutation (51 available)
Foxo4tm1.1Rdp mutation (0 available); any Foxo4 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:118179 )
• other unclassified tumors are seen with higher frequencies (1/9 vs 0 wild-type)
increased pituitary adenoma incidence ( J:118179 )
• females show increased pituitary adenoma (1/5 vs 0 wild-type)
increased Harderian gland tumor incidence ( J:118179 )
• mice show increased incidence of Harderian gland tumors (2/9 vs 1/6 wild-type)
increased ovary tumor incidence ( J:118179 )
• slightly increased incidence of ovarian stromal neoplasms in females (1/5 vs 0 wild-type)

reproductive system
increased ovary tumor incidence ( J:118179 )
• slightly increased incidence of ovarian stromal neoplasms in females (1/5 vs 0 wild-type)

endocrine/exocrine glands
increased pituitary adenoma incidence ( J:118179 )
• females show increased pituitary adenoma (1/5 vs 0 wild-type)
increased Harderian gland tumor incidence ( J:118179 )
• mice show increased incidence of Harderian gland tumors (2/9 vs 1/6 wild-type)
increased ovary tumor incidence ( J:118179 )
• slightly increased incidence of ovarian stromal neoplasms in females (1/5 vs 0 wild-type)

nervous system
increased pituitary adenoma incidence ( J:118179 )
• females show increased pituitary adenoma (1/5 vs 0 wild-type)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory