Phenotypes associated with this allele

• Allele Symbol: Apbb1^tm1Trus
• Allele Name: targeted mutation 1, Tommaso Russo
• Allele ID: MGI:3699106
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apbb1^tm1Trus/Apbb1^tm1Trus	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3701600

Genotype
MGI:3701600

hm1

• Allelic Composition: Apbb1^tm1Trus/Apbb1^tm1Trus
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:118164 )

• mouse embryonic fibroblasts (MEFs) from mutants show higher sensitivity to genotoxic stress like radiation or chemical damage from etoposide, than wild-type cells

increased cellular sensitivity to ionizing radiation ( J:118164 )

• 3 month old male mutants exposed to non lethal doses of radiation show more sensitivity than control littermates, as shown by higher phosphorylation of gamma-H2AX and higher p53 accumulation in brain tissue