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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apbb1tm1Trus
targeted mutation 1, Tommaso Russo
MGI:3699106
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Apbb1tm1Trus/Apbb1tm1Trus involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3701600


Genotype
MGI:3701600
hm1
Allelic
Composition
Apbb1tm1Trus/Apbb1tm1Trus
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apbb1tm1Trus mutation (0 available); any Apbb1 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mouse embryonic fibroblasts (MEFs) from mutants show higher sensitivity to genotoxic stress like radiation or chemical damage from etoposide, than wild-type cells
• 3 month old male mutants exposed to non lethal doses of radiation show more sensitivity than control littermates, as shown by higher phosphorylation of gamma-H2AX and higher p53 accumulation in brain tissue





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory