Analysis Tools
mortality/aging
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• ~50% of homozygotes die within 4.4 months with only ~5.9% surviving to 10 months as result of development of lymphomas
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cardiovascular system
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• extensive tumor infiltrates are found in the heart in moribund mice
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digestive/alimentary system
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• extensive tumor infiltrates are seen in salivary glands in moribund mice
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endocrine/exocrine glands
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• extensive tumor infiltrates are seen in salivary glands in moribund mice
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• complete disruption of normal architecture by monomorphic population of medium-sized lymphoid cells
• tumor cells are found outside the capsule
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• majority of moribund mice have a huge thymus
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• cellularity is reduced to ~33% of wild-type level
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• most tumor cells are CD4+CD8+ with varying contribution by CD8 single positive cells
• in 20% of moribund mice, lymphoma cells in bone marrow and peripheral lymphoid organs consist of CD8 single positive T cells while lymphoma cells in thymus are primarily double positive T cells
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hematopoietic system
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• complete disruption of normal architecture by monomorphic population of medium-sized lymphoid cells
• tumor cells are found outside the capsule
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• majority of moribund mice have a huge thymus
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• cellularity is reduced to ~33% of wild-type level
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• most tumor cells are CD4+CD8+ with varying contribution by CD8 single positive cells
• in 20% of moribund mice, lymphoma cells in bone marrow and peripheral lymphoid organs consist of CD8 single positive T cells while lymphoma cells in thymus are primarily double positive T cells
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• under non-competitive conditions, pro-B cell compartment is increased 2-fold relative to wild-type mice
• B cell numbers normalize at later developmental stages
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• T-cell development is partially blocked at the earliest pro-T cell stage
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• absolute numbers are lower than in heterozygotes and significantly lower than in wild-type
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• absolute numbers are lower than in heterozygotes and significantly lower than in wild-type
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• complete disruption of normal architecture by monomorphic population of medium-sized lymphoid cells
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• all diseased mice show splenomegaly
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immune system
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• complete disruption of normal architecture by monomorphic population of medium-sized lymphoid cells
• tumor cells are found outside the capsule
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• majority of moribund mice have a huge thymus
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• cellularity is reduced to ~33% of wild-type level
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• most tumor cells are CD4+CD8+ with varying contribution by CD8 single positive cells
• in 20% of moribund mice, lymphoma cells in bone marrow and peripheral lymphoid organs consist of CD8 single positive T cells while lymphoma cells in thymus are primarily double positive T cells
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• under non-competitive conditions, pro-B cell compartment is increased 2-fold relative to wild-type mice
• B cell numbers normalize at later developmental stages
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• T-cell development is partially blocked at the earliest pro-T cell stage
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• absolute numbers are lower than in heterozygotes and significantly lower than in wild-type
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• absolute numbers are lower than in heterozygotes and significantly lower than in wild-type
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• complete disruption of normal architecture by monomorphic population of medium-sized lymphoid cells
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• all diseased mice show splenomegaly
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• tumor cells are found outside the capsule
• complete disruption of normal architecture by monomorphic population of medium-sized lymphoid cells
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• all diseased mice show lymphadenopathy
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liver/biliary system
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• extensive tumor infiltrates are found in the liver in moribund mice
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renal/urinary system
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• extensive tumor infiltrates are found in kidneys of moribund mice
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respiratory system
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• extensive tumor infiltrates are found in lungs in moribund mice
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neoplasm
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• mice develop disseminated lymphoma with complete penetrance by 10 months
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• most tumor cells are CD4+CD8+ with varying contribution by CD8 single positive cells
• in 20% of moribund mice, lymphoma cells in bone marrow and peripheral lymphoid organs consist of CD8 single positive T cells while lymphoma cells in thymus are primarily double positive T cells
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growth/size/body
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• all diseased mice show splenomegaly
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