Analysis Tools
renal/urinary system
|
• kidneys exhibit macula densa hyperplasia and the nuclei are piled up in a pseudostratified pattern
|
|
• plasma creatinine levels are elevated indicating a decreased glomerular filtration rate
|
cardiovascular system
| N |
• hearts show neither cardiac hypertrophy or atrophy nor differences in arterial wall thickness
|
|
• on a normal diet, exhibit normal heart rate, however on either a low salt or high salt diet, show a small increase in heart rate
|
|
• lower blood pressure occurs over an entire 24 hour period during times of high and low activity
• on a high salt diet, mean arterial blood pressure increases more in homozygotes (by 5.7 mm Hg) than in wild-type (by 1.9 mm Hg), indicating salt sensitivity, however it is still lower than in wild-type
|
hypotension
(
J:117294
)
|
• markedly reduced mean arterial pressure variability in the midfrequency band indicates a contribution of reduced sympathetic vasomotor tone to the hypotension
|
homeostasis/metabolism
behavior/neurological
|
• locomotor activity is 35% lower than in wild-type
|
nervous system
| N |
• exhibit a normal baroreflex sensitivity on a low, normal, or high salt diet
|
