Phenotypes associated with this allele

• Allele Symbol: Sall4^tm2Ryn
• Allele Name: targeted mutation 2, Ryuichi Nishinakamura
• Allele ID: MGI:3699176
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sall4^tm2Ryn/Sall4^tm2Ryn	involves: 129P2/OlaHsd * C57BL/6J	MGI:3699206
ht2	Sall4^tm2Ryn/Sall4^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3699208
cx3	Sall1^tm2Ryn/Sall1^+ Sall4^tm2Ryn/Sall4^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3699211

Genotype
MGI:3699206

hm1

• Allelic Composition: Sall4^tm2Ryn/Sall4^tm2Ryn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:118119 )

• phenotype is stated to be identical to that of Sall4^tm1Ryn homozygotes, however no data is presented in J:118119

embryo

abnormal embryonic tissue morphology ( J:118119 )

abnormal inner cell mass morphology ( J:118119 )

Genotype
MGI:3699208

ht2

• Allelic Composition: Sall4^tm2Ryn/Sall4⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

premature death ( J:118119 )

postnatal lethality, incomplete penetrance ( J:118119 )

prenatal lethality, complete penetrance ( J:118119 )

• phenotype is stated to be identical to that of Sall4^tm1Ryn homozygotes, however no data is presented in J:118119

digestive/alimentary system

abnormal anus morphology ( J:118119 )

megacolon ( J:118119 )

abnormal rectum morphology ( J:118119 )

cardiovascular system

ventricular septal defect ( J:118119 )

limbs/digits/tail

kinked tail ( J:118119 )

nervous system

exencephaly ( J:118119 )

Genotype
MGI:3699211

cx3

• Allelic Composition: Sall1^tm2Ryn/Sall1⁺; Sall4^tm2Ryn/Sall4⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

perinatal lethality, complete penetrance ( J:118119 )

• none survive after birth

renal/urinary system

absent kidney ( J:118119 )

• 6 of 38 exhibit bilateral renal agenesis

single kidney ( J:118119 )

• 10 of 38 exhibit unilateral renal agenesis

cardiovascular system

ventricular septal defect ( J:118119 )

• 70% of E17.5-18.5 mutants exhibit ventricular septum defects

digestive/alimentary system

abnormal anus morphology ( J:118119 )

• 68.8% of mutants at E17.5-18.5 exhibit anorectal malformations

anal stenosis ( J:118119 )

• exhibit anal stenosis at E17.5

abnormal rectum morphology ( J:118119 )

• 68.8% of mutants at E17.5-18.5 exhibit anorectal malformations

nervous system

exencephaly ( J:118119 )

• seen in 44.7% of E13.5-P0 mutants