Phenotypes associated with this allele

• Allele Symbol: Stoml3^tm1Glwn
• Allele Name: targeted mutation 1, Gary R Lewin
• Allele ID: MGI:3699212
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stoml3^tm1Glwn/Stoml3^tm1Glwn	involves: 129P2/OlaHsd * C57BL/6N	MGI:3700232

Genotype
MGI:3700232

hm1

• Allelic Composition: Stoml3^tm1Glwn/Stoml3^tm1Glwn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hyporesponsive to tactile stimuli ( J:118239 )

• mutants respond significantly only to the coarsest grid in a test for responses to a grating cue in the dark, whereas controls show a significant response to all grids tested

abnormal mechanical nociception ( J:118239 )

• after chronic constriction injury (CCI) of the sciatic nerve, mutants do not show any hyperalgesia (threshold decreases to ~1 gram) until the third day after injury, compared to wild-type mice which developed allodynia within a few days, with mechanical thresholds decreasing from 3 grams to less than 0.25 grams

nervous system

abnormal nerve fiber response ( J:118239 )

• mutants show an increase in mechanically insensitive A fibers (Abeta and Agamma) compared to wild-type

• percentage of insensitive C fibers is not significantly changed

• abount 36% of isolated sensory neurons from mutant mice show no current response to mechanical stimulation of the neurites; proportion of cells displaying slowly or rapidly adapting mechanically elevated currents is slightly reduced compared to wild-type