mortality/aging
N |
• no significant loss of homozygotes is detected
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cellular
N |
• MEFs arrest after exposure to 6 Gy or 12 Gy irradiation similar to wild-type MEFs and unlike Trp53 null cells
• sensitivity to adriamycin-induced apoptosis is similar to wild-type MEFs, unlike Trp53 null cells which show increased resistance
• thymocyte sensitivity to gamma-irradiation-induced apoptosis is similar to wild-type cells unlike Trp53tm3Wahl homozygotes which show increased resistance
|