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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trp53tm5Wahl
targeted mutation 5, Geoffrey M Wahl
MGI:3699248
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trp53tm5Wahl/Trp53tm5Wahl involves: 129S4/SvJae MGI:3700137


Genotype
MGI:3700137
hm1
Allelic
Composition
Trp53tm5Wahl/Trp53tm5Wahl
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm5Wahl mutation (0 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• no significant loss of homozygotes is detected

cellular
N
• MEFs arrest after exposure to 6 Gy or 12 Gy irradiation similar to wild-type MEFs and unlike Trp53 null cells
• sensitivity to adriamycin-induced apoptosis is similar to wild-type MEFs, unlike Trp53 null cells which show increased resistance
• thymocyte sensitivity to gamma-irradiation-induced apoptosis is similar to wild-type cells unlike Trp53tm3Wahl homozygotes which show increased resistance





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory