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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pde8atm1Dgen
targeted mutation 1, Deltagen
MGI:3699271
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pde8atm1Dgen/Pde8atm1Dgen B6.129P2-Pde8atm1Dgen MGI:3699840
hm2
 		Pde8atm1Dgen/Pde8atm1Dgen involves: 129P2/OlaHsd * C57BL/6J MGI:5427852
cx3
 		Pde8atm1Dgen/Pde8atm1Dgen
Pde8btm1Dgen/Pde8btm1Dgen 		involves: 129P2/OlaHsd * C57BL/6 MGI:5526100


Genotype
MGI:3699840
hm1
Allelic
Composition		 Pde8atm1Dgen/Pde8atm1Dgen
Genetic
Background		 B6.129P2-Pde8atm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde8atm1Dgen mutation (2 available); any Pde8a mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal testosterone level ( J:118251 )
• isolated Leydig cells show higher (~4-fold, 34.5 ng/ml of testosterone released/cell number) basal levels of testosterone production as determined by 3beta-hydroxysteroid dehydrogenase activity after luteinizing hormone stimulation compared to wild-type (8.48 ng/ml)
abnormal enzyme/coenzyme activity ( J:118251 )
• 3-beta-hydroxysteroid dehydrogenase activity is elevated in mutant Leydig cells after stimulation with luteinizing hormone




Genotype
MGI:5427852
hm2
Allelic
Composition		 Pde8atm1Dgen/Pde8atm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde8atm1Dgen mutation (2 available); any Pde8a mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:82809 )
• homozygous mutants displayed a decreased response threshold to metrazol
decreased thermal nociceptive threshold ( J:82809 )
• homozygous mutants displayed a decreased response threshold on the Hot Plate test

nervous system
increased susceptibility to pharmacologically induced seizures ( J:82809 )
• homozygous mutants displayed a decreased response threshold to metrazol




Genotype
MGI:5526100
cx3
Allelic
Composition		 Pde8atm1Dgen/Pde8atm1Dgen
Pde8btm1Dgen/Pde8btm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde8atm1Dgen mutation (2 available); any Pde8a mutation (55 available)
Pde8btm1Dgen mutation (0 available); any Pde8b mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:203335 )
• PF-04957325 (a PDE8-selective inhibitor) has no affect on basal steroid production unlike in wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory