Analysis Tools
mortality/aging
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• males survive until birth but die on first postnatal day
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cardiovascular system
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• blood vessels in brain are dilated
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• males show abnormal outflow tracts including interrupted aortic arch, but less severe than Flnatm1.1Caw mutant males
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• some adherens junctions (AJs) are unidentifiable, with excessive membrane ruffles at sites where AJs normally form
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• endothelial cells are poorly organized with clusters or multiple layers and gaps in outflow tract
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• males show abnormal outflow tracts including PTA, but less severe than Flnatm1.1Caw mutant males
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• endothelial cells are poorly organized with clusters or multiple layers and gaps in endocardial cushion
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homeostasis/metabolism
nervous system
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• at E14.5, surviving mutants have smaller but grossly normal brains, with thinner cortical plate
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behavior/neurological
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N |
• no heterotopic neurons or migratory arrest are seen in mutant brains
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