Phenotypes associated with this allele

• Allele Symbol: Flna^tm1.2Caw
• Allele Name: targeted mutation 1.2, Christopher A Walsh
• Allele ID: MGI:3699306
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Flna^tm1.2Caw/Flna^+	involves: 129S4/SvJae * C57BL/6	MGI:3699952
ot2	Flna^tm1.2Caw/Y	involves: 129S4/SvJae * C57BL/6	MGI:3699951

Genotype
MGI:3699952

ht1

• Allelic Composition: Flna^tm1.2Caw/Flna⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:118252 )

♀ • about 20% of females die in the initial 3-4 months of life with many anomalies

preweaning lethality, incomplete penetrance ( J:118252 )

♀ • some females die early; only ~50% of expected female heterozygous mice are observed at weaning

postnatal lethality, incomplete penetrance ( J:118252 )

♀ • some females die after birth; only about 50% of expected female heterozygous mice are observed at weaning

cardiovascular system

abnormal heart morphology ( J:118252 )

♀

dilated heart ( J:118252 )

♀ • some females that die at 3-4 months display heart dilation

hematopoietic system

increased leukocyte cell number ( J:118252 )

♀ • leukocytosis seen in some dead females at 3-4 months

homeostasis/metabolism

abnormal thrombosis ( J:118252 )

♀ • some females that die at 3-4 months have liver thrombi

edema ( J:118252 )

♀ • some females that die at 3-4 months show lung edema

immune system

increased leukocyte cell number ( J:118252 )

♀ • leukocytosis seen in some dead females at 3-4 months

liver/biliary system

hepatic necrosis ( J:118252 )

♀ • seen in some dead females at 3-4 months

reproductive system

reduced female fertility ( J:118252 )

♀ • heterozygous females are poor breeders

respiratory system

emphysema ( J:118252 )

♀ • some females that die at 3-4 months display emphysema

Genotype
MGI:3699951

ot2

• Allelic Composition: Flna^tm1.2Caw/Y
• Genetic Background: involves: 129S4/SvJae * C57BL/6

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:118252 )

♂ • male embryos die by E14.5

cardiovascular system

abnormal blood vessel morphology ( J:118252 )

♂ • some male embryos display dilated subcutaneous vasculature

♂ • blood vessels may be coarse and dilated

interrupted aortic arch ( J:118252 )

♂ • observed in mutants (13/13 males) at E13.5-14.5

abnormal intersomitic vessel morphology ( J:118252 )

♂ • intersomitic vessels are abnormal

♂ • intersomitic vessels extend aberrant branches and sprouts into somitic tissues

abnormal angiogenesis ( J:118252 )

♂ • intersomitic vessels are abnormal

♂ • intersomitic vessels extend aberrant branches and sprouts into somitic tissues

♂ • at E12, mutants display disorganized and exuberant blood vessels; at E14, vessels are not remodeled into fine branches

abnormal vascular regression ( J:118252 )

♂ • vascular remodeling is defective

abnormal cardiac outflow tract development ( J:118252 )

♂

persistent truncus arteriosus ( J:118252 )

♂ • observed in all mutants (13/13 males) at E13.5-14.5; type I PTA with single outflow tract overriding right and left ventricles, outflow tract valve defects, and ventricular septal defect

atrial septal defect ( J:118252 )

♂ • embryos show atrial and ventricular septal defects, with a single ventricle

common ventricle ( J:118252 )

♂

ventricular septal defect ( J:118252 )

♂ • all embryos display incomplete septation of the ventricles

hemorrhage ( J:118252 )

♂ • male embryos display hemorrhage

homeostasis/metabolism

edema ( J:118252 )

♂ • some male embryos display edema

cellular

abnormal vascular regression ( J:118252 )

♂ • vascular remodeling is defective