Phenotypes associated with this allele

• Allele Symbol: Fgfr2^tm2Schl
• Allele Name: targeted mutation 2, Joseph Schlessinger
• Allele ID: MGI:3699314
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfr2^tm2Schl/Fgfr2^tm2Schl	involves: 129S1/Sv * BALB/c * C57BL/6	MGI:3699819
ht2	Fgfr2^tm2Schl/Fgfr2^+	involves: 129S1/Sv * BALB/c * C57BL/6	MGI:3699820

Genotype
MGI:3699819

hm1

• Allelic Composition: Fgfr2^tm2Schl/Fgfr2^tm2Schl
• Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cleft palate, tracheal defects and joint analysis in Fgfr2^tm1Schl/Fgfr2^tm1Schl and Fgfr2^tm2Schl/Fgfr2^tm2Schl mice

craniofacial

palatal shelves fail to meet at midline ( J:118299 )

cleft palate ( J:118299 )

• mice have cleft palate

digestive/alimentary system

palatal shelves fail to meet at midline ( J:118299 )

cleft palate ( J:118299 )

• mice have cleft palate

respiratory system

abnormal tracheal cartilage morphology ( J:118299 )

• cartilaginous rings are not separated by fibrous tissue, resulting in formation of tracheal cartilaginous sleeve (TCS - continuous tube-shaped cartilaginous core)

skeleton

abnormal tracheal cartilage morphology ( J:118299 )

• cartilaginous rings are not separated by fibrous tissue, resulting in formation of tracheal cartilaginous sleeve (TCS - continuous tube-shaped cartilaginous core)

growth/size/body

palatal shelves fail to meet at midline ( J:118299 )

cleft palate ( J:118299 )

• mice have cleft palate

Genotype
MGI:3699820

ht2

• Allelic Composition: Fgfr2^tm2Schl/Fgfr2⁺
• Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:118299 )

• mice are normal and indistinguishable from wild-type, with no craniofacial phenotype like Fgfr2^tm2Schl heterozygotes