Analysis Tools|
Allele Symbol Allele Name Allele ID |
Kcne2tm1Gwab targeted mutation 1, Geoffrey W Abbott MGI:3699589 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Kcne2tm1Gwab/Kcne2tm1Gwab mice have enlarged stomachs
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• marked hyperplasia of the glandular stomach
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• intracellular canaliculi are much larger and displace the mitochondria to the cell periphery
• however, no obvious abnormalities in the chief cells are detected
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• gastric glandular hyperplasia with lengthening of the fundus and neck portions of the stomach
• hyperplastic glands are primarily lined with tall, columnar cells with excess cytoplasm that appear to be mucous neck and/or chief cells
• hyperplasia appears to only affect the non-acid secretory cell types
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• mild to moderate numbers of neutrophils are seen scattered through the lamina propria basally, submucosa, and muscularis
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• at 12 - 15 weeks of age about a 4-fold increase in stomach mass is seen
• enlarged stomachs have prominent rugal folds and marked hyperplasia of the glandular stomach
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• mice display achlorhydria
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• acid loaded parietal cells have a much lower rate of proton secretion, about 0.01 pH units/minute compared to about 0.1 units/minute in wild-type controls
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• mean luminal pH in the stomach under basal conditions is 6.5 +/- 0.2 compared to 3.9 +/- 0.1 in wild-type controls
• luminal pH is not significantly altered by histamine, unlike in wild-type controls
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• marked elevation in serum gastrin levels
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• intracellular canaliculi are much larger and displace the mitochondria to the cell periphery
• however, no obvious abnormalities in the chief cells are detected
|
|
• gastric glandular hyperplasia with lengthening of the fundus and neck portions of the stomach
• hyperplastic glands are primarily lined with tall, columnar cells with excess cytoplasm that appear to be mucous neck and/or chief cells
• hyperplasia appears to only affect the non-acid secretory cell types
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• parietal and chief cell morphology appears similar to wild-type controls despite the decrease in stomach pH
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• acid loaded parietal cells have a lower rate of proton secretion, about 0.05 pH units/minute compared to about 0.1 units/minute in wild-type controls
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• mice display hypochlohydria
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• mean luminal pH in the stomach under basal conditions is 4.6 +/- 0.2 compared to 3.9 +/- 0.1 in wild-type controls
• however, luminal pH is significantly altered by histamine similar to wild-type controls and unlike homozygous mice
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| N |
• serum gastrin levels are similar to wild-type controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• stomachs are 2-fold heavier than in wild-type mice
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• compared with wild-type mice and Kcne2tm1Gwab homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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