About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myhca-Casq2)418Egk
transgene insertion 418, Evangelia G Kranias
MGI:3699603
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myhca-Casq2)418Egk/0 involves: FVB/N MGI:3715375


Genotype
MGI:3715375
tg1
Allelic
Composition
Tg(Myhca-Casq2)418Egk/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myhca-Casq2)418Egk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mild myocyte hypertrophy in the left ventricular free walls and intraventricular septa
• increase in heart/body weight ratio is associated with increases in expression of fetal genes
• cardiomyocyte (isolated) shortening and maximal rates of shortening are depressed by 46 and 60%, respectively
• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of contraction of hearts
• cardiomyocyte relengthening rate is depressed by 60%
• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of relaxation of hearts
• the calcium transient amplitude of cardiomyocytes is depressed (45%), although the SR calcium storage capacity is augmented
• cardiomyocytes exhibit a decrease in L-type calcium current density and prolongation of the channels inactivation kinetics without changes in sodium-calcium exchanger current density

muscle
• mild myocyte hypertrophy in the left ventricular free walls and intraventricular septa
• cardiomyocyte (isolated) shortening and maximal rates of shortening are depressed by 46 and 60%, respectively
• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of contraction of hearts
• cardiomyocyte relengthening rate is depressed by 60%
• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of relaxation of hearts

growth/size/body
• increase in heart/body weight ratio is associated with increases in expression of fetal genes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory