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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myhca-Casq2)418Egk
transgene insertion 418, Evangelia G Kranias
MGI:3699603
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myhca-Casq2)418Egk/0 involves: FVB/N MGI:3715375


Genotype
MGI:3715375
tg1
Allelic
Composition
Tg(Myhca-Casq2)418Egk/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myhca-Casq2)418Egk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mild myocyte hypertrophy in the left ventricular free walls and intraventricular septa
• increase in heart/body weight ratio is associated with increases in expression of fetal genes
• cardiomyocyte (isolated) shortening and maximal rates of shortening are depressed by 46 and 60%, respectively
• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of contraction of hearts
• cardiomyocyte relengthening rate is depressed by 60%
• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of relaxation of hearts
• the calcium transient amplitude of cardiomyocytes is depressed (45%), although the SR calcium storage capacity is augmented
• cardiomyocytes exhibit a decrease in L-type calcium current density and prolongation of the channels inactivation kinetics without changes in sodium-calcium exchanger current density

muscle
• mild myocyte hypertrophy in the left ventricular free walls and intraventricular septa
• cardiomyocyte (isolated) shortening and maximal rates of shortening are depressed by 46 and 60%, respectively
• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of contraction of hearts
• cardiomyocyte relengthening rate is depressed by 60%
• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of relaxation of hearts

growth/size/body
• increase in heart/body weight ratio is associated with increases in expression of fetal genes





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory