cardiovascular system
• mild myocyte hypertrophy in the left ventricular free walls and intraventricular septa
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• increase in heart/body weight ratio is associated with increases in expression of fetal genes
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• cardiomyocyte (isolated) shortening and maximal rates of shortening are depressed by 46 and 60%, respectively
• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of contraction of hearts
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• cardiomyocyte relengthening rate is depressed by 60%
• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of relaxation of hearts
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• the calcium transient amplitude of cardiomyocytes is depressed (45%), although the SR calcium storage capacity is augmented
• cardiomyocytes exhibit a decrease in L-type calcium current density and prolongation of the channels inactivation kinetics without changes in sodium-calcium exchanger current density
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muscle
• mild myocyte hypertrophy in the left ventricular free walls and intraventricular septa
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• cardiomyocyte (isolated) shortening and maximal rates of shortening are depressed by 46 and 60%, respectively
• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of contraction of hearts
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• cardiomyocyte relengthening rate is depressed by 60%
• left ventricular function analysis in Langerdorff perfused hearts and closed-chest anesthetized mice show a depressed rate of relaxation of hearts
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growth/size/body
• increase in heart/body weight ratio is associated with increases in expression of fetal genes
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