Phenotypes associated with this allele

• Allele Symbol: Grin2b^{tm1(GRIN2A/GRIN2B)Twr}
• Allele Name: targeted mutation 1, Thomas W Rosahl
• Allele ID: MGI:3699608
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2b^tm1(GRIN2A/GRIN2B)Twr/Grin2b^tm1(GRIN2A/GRIN2B)Twr	involves: 129S7/SvEvBrd * C57BL/6	MGI:3700743

Genotype
MGI:3700743

hm1

• Allelic Composition: Grin2b^{tm1(GRIN2A/GRIN2B)Twr}/Grin2b^{tm1(GRIN2A/GRIN2B)Twr}
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal NMDA-mediated synaptic currents ( J:116524 )

• decreased glycine sensitivity in hippocampal neurons

• reduction in the mean peak amplitude of hippocampal neurons in response to NMDA (1mM) with glycine (300 uM)

behavior/neurological

behavior/neurological phenotype ( J:116524 )

N • exploratory activity in untreated mice and in mice treated with MK801 is similar to wild-type controls