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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Furintm1Jwmc
targeted mutation 1, John W M Creemers
MGI:3700008
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Furintm1Jwmc/Furintm1Jwmc involves: 129P2/OlaHsd * C57BL/6J MGI:3700793
cn2
 		Furintm1Jwmc/Furintm1.1Jwmc
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/6J * CBA MGI:3700792
cn3
 		Furintm1Jwmc/Furintm1Jwmc
Tg(Zp3-cre)3Mrt/0 		involves: 129P2/OlaHsd * C57BL/6J * CBA/J MGI:6856673
cn4
 		Furintm1Jwmc/Furintm1Jwmc
Tg(Gdf9-icre)5092Coo/0 		involves: 129P2/OlaHsd * C57BL/6J * CBA/J MGI:6856674
cn5
 		Furintm1Jwmc/Furintm1Jwmc
Tg(Cd4-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5544321


Genotype
MGI:3700793
hm1
Allelic
Composition		 Furintm1Jwmc/Furintm1Jwmc
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Furintm1Jwmc mutation (0 available); any Furin mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:118515 )
• mice are viable, fertile and normal in appearance




Genotype
MGI:3700792
cn2
Allelic
Composition		 Furintm1Jwmc/Furintm1.1Jwmc
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Furintm1.1Jwmc mutation (1 available); any Furin mutation (48 available)
Furintm1Jwmc mutation (0 available); any Furin mutation (48 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver/biliary system phenotype ( J:118515 )
N
• conditional mice show no liver phenotype




Genotype
MGI:6856673
cn3
Allelic
Composition		 Furintm1Jwmc/Furintm1Jwmc
Tg(Zp3-cre)3Mrt/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Furintm1Jwmc mutation (0 available); any Furin mutation (48 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal oocyte morphology ( J:272231 )
• loss of connexin 37 staining at the surface of oocytes indicates impaired gap junctions between oocytes and surrounding granulosa cells at the early secondary follicle stage
• metaphase II (MII) oocytes collected after superovulation exhibit poor quality with degenerated first polar bodies and severely abnormal spindles
abnormal primary polar body morphology ( J:272231 )
• metaphase II (MII) oocytes collected after superovulation exhibit degenerated first polar bodies
abnormal meiotic spindle morphology ( J:272231 )
• metaphase II (MII) oocytes collected after superovulation exhibit severely abnormal spindles
increased granulosa cell apoptosis ( J:272231 )
• at P35, TUNEL analysis showed severe apoptosis of granulosa cells in late preantral follicles and antral follicles
• however, no apparent apoptosis is detected in early secondary follicles
decreased granulosa cell proliferation ( J:272231 )
• PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age
abnormal secondary ovarian follicle number ( J:272231 )
• at 6 and 8 weeks of age, number of early secondary follicles is significantly increased while the number of large growing (late preantral) follicles is markedly decreased
decreased tertiary ovarian follicle number ( J:272231 )
• number of antral follicles is markedly decreased
increased atretic ovarian follicle number ( J:272231 )
• large antral follicles exhibit degeneration at 8 weeks of age; few or almost no late growing follicles or antral follicles are observed, suggesting atresia of follicles beyond the early secondary stage
impaired ovarian folliculogenesis ( J:272231 )
• at 6 weeks of age, the number of early secondary follicles is significantly increased while the number of large growing (late preantral) follicles and antral follicles is markedly decreased, indicating that primary follicles fail to develop beyond the early secondary follicle stage
small ovary ( J:272231 )
• ovaries are smaller at P42
decreased superovulation rate ( J:272231 )
• following induction of ovulation with exogenous PMSG + hCG, the number of ovulated oocytes per 6-wk-old female is significantly lower than that in control females
anovulation ( J:272231 )
• females fail to ovulate during a natural ovulation assay
failure of superovulation ( J:272231 )
• 8-wk-old or older females cannot be induced to ovulate anymore
female infertility ( J:272231 )
• when mated with fertile males for 6 months, females fail to produce any progeny indicating complete female infertility

cellular
abnormal oocyte morphology ( J:272231 )
• loss of connexin 37 staining at the surface of oocytes indicates impaired gap junctions between oocytes and surrounding granulosa cells at the early secondary follicle stage
• metaphase II (MII) oocytes collected after superovulation exhibit poor quality with degenerated first polar bodies and severely abnormal spindles
abnormal primary polar body morphology ( J:272231 )
• metaphase II (MII) oocytes collected after superovulation exhibit degenerated first polar bodies
abnormal meiotic spindle morphology ( J:272231 )
• metaphase II (MII) oocytes collected after superovulation exhibit severely abnormal spindles
increased granulosa cell apoptosis ( J:272231 )
• at P35, TUNEL analysis showed severe apoptosis of granulosa cells in late preantral follicles and antral follicles
• however, no apparent apoptosis is detected in early secondary follicles
decreased granulosa cell proliferation ( J:272231 )
• PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age

endocrine/exocrine glands
increased granulosa cell apoptosis ( J:272231 )
• at P35, TUNEL analysis showed severe apoptosis of granulosa cells in late preantral follicles and antral follicles
• however, no apparent apoptosis is detected in early secondary follicles
decreased granulosa cell proliferation ( J:272231 )
• PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age
abnormal secondary ovarian follicle number ( J:272231 )
• at 6 and 8 weeks of age, number of early secondary follicles is significantly increased while the number of large growing (late preantral) follicles is markedly decreased
decreased tertiary ovarian follicle number ( J:272231 )
• number of antral follicles is markedly decreased
increased atretic ovarian follicle number ( J:272231 )
• large antral follicles exhibit degeneration at 8 weeks of age; few or almost no late growing follicles or antral follicles are observed, suggesting atresia of follicles beyond the early secondary stage
impaired ovarian folliculogenesis ( J:272231 )
• at 6 weeks of age, the number of early secondary follicles is significantly increased while the number of large growing (late preantral) follicles and antral follicles is markedly decreased, indicating that primary follicles fail to develop beyond the early secondary follicle stage
small ovary ( J:272231 )
• ovaries are smaller at P42




Genotype
MGI:6856674
cn4
Allelic
Composition		 Furintm1Jwmc/Furintm1Jwmc
Tg(Gdf9-icre)5092Coo/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Furintm1Jwmc mutation (0 available); any Furin mutation (48 available)
Tg(Gdf9-icre)5092Coo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased granulosa cell proliferation ( J:272231 )
• PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age
increased secondary ovarian follicle number ( J:272231 )
• number of early secondary follicles is significantly increased at 6 weeks of age
impaired ovarian folliculogenesis ( J:272231 )
• ovarian follicle development is arrested at the early secondary follicle stage
• however, number of primordial follicles is normal at 2 months of age, suggesting that survival and activation of primordial follicles is unaffected

cellular
decreased granulosa cell proliferation ( J:272231 )
• PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age

endocrine/exocrine glands
decreased granulosa cell proliferation ( J:272231 )
• PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age
increased secondary ovarian follicle number ( J:272231 )
• number of early secondary follicles is significantly increased at 6 weeks of age
impaired ovarian folliculogenesis ( J:272231 )
• ovarian follicle development is arrested at the early secondary follicle stage
• however, number of primordial follicles is normal at 2 months of age, suggesting that survival and activation of primordial follicles is unaffected




Genotype
MGI:5544321
cn5
Allelic
Composition		 Furintm1Jwmc/Furintm1Jwmc
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Furintm1Jwmc mutation (0 available); any Furin mutation (48 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal regulatory T cell physiology ( J:204761 )
• regulatory T cells fail to drive Th17 differentiation

immune system
abnormal regulatory T cell physiology ( J:204761 )
• regulatory T cells fail to drive Th17 differentiation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory