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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(KRT14-Esr1/HRAS)1Pkha
transgene insertion 1, Paul A Khavari
MGI:3700054
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(KRT14-Esr1/HRAS)1Pkha/0
Trim27Gt(XP0484)Wtsi/Trim27Gt(XP0484)Wtsi
involves: 129P2/OlaHsd * C57BL/6 MGI:5446918
tg2
Tg(KRT14-Esr1/HRAS)1Pkha/0 involves: C57BL/6 MGI:3700917


Genotype
MGI:5446918
cx1
Allelic
Composition
Tg(KRT14-Esr1/HRAS)1Pkha/0
Trim27Gt(XP0484)Wtsi/Trim27Gt(XP0484)Wtsi
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-Esr1/HRAS)1Pkha mutation (1 available)
Trim27Gt(XP0484)Wtsi mutation (0 available); any Trim27 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in mouse embryonic fibroblasts




Genotype
MGI:3700917
tg2
Allelic
Composition
Tg(KRT14-Esr1/HRAS)1Pkha/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-Esr1/HRAS)1Pkha mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• with continuous 4-hydroxy-testosterone (4OHT) application, hyperkeratosis is observed after 3 weeks, increasing in severity with transgene expression level
• with continuous 4-hydroxy-testosterone (4OHT) application, skin thickening is observed after 3 weeks, increasing in severity with transgene expression level





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory