Phenotypes associated with this allele

• Allele Symbol: Prdx3^{Gt(Betageo-puro)711Lex}
• Allele Name: gene trap 711, Lexicon Genetics
• Allele ID: MGI:3700138
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prdx3^Gt(Betageo-puro)711Lex/Prdx3^Gt(Betageo-puro)711Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3700506

Genotype
MGI:3700506

hm1

• Allelic Composition: Prdx3^{Gt(Betageo-puro)711Lex}/Prdx3^{Gt(Betageo-puro)711Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:118595 )

• mutants look smaller than wild-type littermates; at 7 months, a 14.3% reduction in body weight compared to wild-type is observed

immune system

lung inflammation ( J:118595 )

• after LPS treatment, lung injury is more severe in mutants than in wild-type; mutants show hemorrhaged alveoli, massive inflammatory leukocyte infiltration, and thickened airways, while wild-type show alveolar effusion and moderate numbers of inflammatory cells

respiratory system

lung inflammation ( J:118595 )

• after LPS treatment, lung injury is more severe in mutants than in wild-type; mutants show hemorrhaged alveoli, massive inflammatory leukocyte infiltration, and thickened airways, while wild-type show alveolar effusion and moderate numbers of inflammatory cells

cellular

abnormal cell physiology ( J:118595 )

• at low and high doses of LPS, 33.5% and 62.5%, respectively, of alveoli in mutant lungs are positive for oxidized DNA marker,8-OHdG whereas control lungs show no 8-OHdG at low or high doses of LPS