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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Apobec3Gt(XN450)Byg
gene trap XN450, BayGenomics
MGI:3700142
Summary 5 genotypes


Genotype
MGI:3809803
hm1
Allelic
Composition		 Apobec3Gt(XN450)Byg/Apobec3Gt(XN450)Byg
Genetic
Background		 129P2/OlaHsd-Apobec3Gt(XN450)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation (3 available); any Apobec3 mutation (127 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin level ( J:138778 )
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is almost two orders of magnitude lower than in controls
increased susceptibility to Retroviridae infection ( J:138778 )
• 16-week old mice mice infected with Friend virus have much higher virus counts in their blood 8 days later as C57BL/6 controls

hematopoietic system
abnormal immunoglobulin level ( J:138778 )
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is almost two orders of magnitude lower than in controls




Genotype
MGI:3809802
hm2
Allelic
Composition		 Apobec3Gt(XN450)Byg/Apobec3Gt(XN450)Byg
Genetic
Background		 B6.129P2-Apobec3Gt(XN450)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation (3 available); any Apobec3 mutation (127 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin level ( J:138778 )
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is almost two orders of magnitude lower than in controls
increased susceptibility to Retroviridae infection ( J:138778 )
• 16-week old mice mice infected with Friend virus have 6.2 times as much virus in their blood 8 days later as C57BL/6 controls

hematopoietic system
abnormal immunoglobulin level ( J:138778 )
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is almost two orders of magnitude lower than in controls




Genotype
MGI:3700666
hm3
Allelic
Composition		 Apobec3Gt(XN450)Byg/Apobec3Gt(XN450)Byg
Genetic
Background		 B6.Cg-Apobec3Gt(XN450)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation (3 available); any Apobec3 mutation (127 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to Retroviridae infection ( J:118597 )
• mice infected subcutaneously with MMTV(RIII) display a more rapid and extensive spread of infection compared to wild-type mice
• these mice also display increases in activated B and T cells in the draining and non-draining lymph nodes




Genotype
MGI:3809805
cx4
Allelic
Composition		 Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2b
Genetic
Background		 involves: A.BY * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation (3 available); any Apobec3 mutation (127 available)
Apobec3Rfv3-s mutation (1 available); any Apobec3 mutation (127 available)
H2b mutation (30 available); any H2 mutation (282 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin level ( J:138778 )
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in littermate controls

hematopoietic system
abnormal immunoglobulin level ( J:138778 )
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in littermate controls




Genotype
MGI:3809804
cx5
Allelic
Composition		 Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2d
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation (3 available); any Apobec3 mutation (127 available)
Apobec3Rfv3-s mutation (1 available); any Apobec3 mutation (127 available)
H2b mutation (30 available); any H2 mutation (282 available)
H2d mutation (23 available); any H2 mutation (282 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to Retroviridae infection induced morbidity/mortality ( J:138778 )
• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

immune system
abnormal immunoglobulin level ( J:138778 )
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls
increased susceptibility to Retroviridae infection ( J:138778 )
• 16-week old mice mice infected with Friend virus have an order of magnitude more virus in their blood 8 days later than in littermate controls
• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls
increased susceptibility to Retroviridae infection induced morbidity/mortality ( J:138778 )
• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

hematopoietic system
abnormal immunoglobulin level ( J:138778 )
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory