Phenotypes associated with this allele

• Allele Symbol: Ing1^{Gt(OST206270)Lex}
• Allele Name: gene trap OST206270, Lexicon Genetics
• Allele ID: MGI:3700145
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ing1^Gt(OST206270)Lex/Ing1^Gt(OST206270)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3700392
ht2	Ing1^Gt(OST206270)Lex/Ing1^+	involves: 129S5/SvEvBrd * C57BL/6	MGI:3700395
cx3	Ing1^Gt(OST206270)Lex/Ing1^Gt(OST206270)Lex Trp53^tm1Brd/Trp53^tm1Brd	involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6	MGI:3700393

Genotype
MGI:3700392

hm1

• Allelic Composition: Ing1^{Gt(OST206270)Lex}/Ing1^{Gt(OST206270)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:118602 )

• mice weigh ~15% less at weaning compared to heterozygous and wild-type littermates

hematopoietic system

increased thymocyte apoptosis ( J:118602 )

• after exposure to 10-Gy ionizing radiation, thymocytes show increased apoptosis compared to wild-type or Trp53-null cells

decreased thymocyte number ( J:118602 )

• at 6 weeks, thymocyte number recovered from mutants are reduced 2-fold compared to wild-type

immune system

increased thymocyte apoptosis ( J:118602 )

• after exposure to 10-Gy ionizing radiation, thymocytes show increased apoptosis compared to wild-type or Trp53-null cells

decreased thymocyte number ( J:118602 )

• at 6 weeks, thymocyte number recovered from mutants are reduced 2-fold compared to wild-type

neoplasm

increased B cell derived lymphoma incidence ( J:118602 )

• ~50% of mice develop tumors in the spleen or peripheral lymph nodes by 22 months of age, compared to no tumors in wild-type mice over that period

cellular

abnormal cell physiology ( J:118602 )

• MEFs show increased survival and growth relative to wild-type when plated at low densities

increased cellular sensitivity to ionizing radiation ( J:118602 )

• after exposure to 10-Gy ionizing radiation, only 31.7% of CD4/CD8 double positive T cells survive compared to 45.5% in wild-type

increased thymocyte apoptosis ( J:118602 )

• after exposure to 10-Gy ionizing radiation, thymocytes show increased apoptosis compared to wild-type or Trp53-null cells

increased fibroblast apoptosis ( J:118602 )

• MEFs transfected with retrovirus encoding a puromycin resistance gene are highly sensitive to adriamycin-induced apoptosis compared to transfected wild-type cells

increased fibroblast proliferation ( J:118602 )

• primary fibroblasts proliferated faster than wild-type but not as fast as Trp53-null fibroblasts

endocrine/exocrine glands

increased thymocyte apoptosis ( J:118602 )

• after exposure to 10-Gy ionizing radiation, thymocytes show increased apoptosis compared to wild-type or Trp53-null cells

decreased thymocyte number ( J:118602 )

• at 6 weeks, thymocyte number recovered from mutants are reduced 2-fold compared to wild-type

Genotype
MGI:3700395

ht2

• Allelic Composition: Ing1^{Gt(OST206270)Lex}/Ing1⁺
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

neoplasm

increased B cell derived lymphoma incidence ( J:118602 )

• ~40% of mice develop tumors in the spleen or peripheral lymph nodes by 22 months of age, compared to no tumors in wild-type mice over that period

Genotype
MGI:3700393

cx3

• Allelic Composition: Ing1^{Gt(OST206270)Lex}/Ing1^{Gt(OST206270)Lex}; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

cellular

increased cellular sensitivity to ionizing radiation ( J:118602 )

• after exposure to 10-Gy ionizing radiation, only 56.3% of CD4/CD8 double positive T cells survive compared to 78.5% in Trp53-null mice

increased cell proliferation ( J:118602 )

• rate of growth is higher than in Trp53-single null cells