About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Cdh5-cre/ERT2)CIVE23Mlia
transgene insertion CIVE23, M Luisa Iruela-Arispe
MGI:3700149
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre/ERT2)CIVE23Mlia/0
Tg(TRAMP)8247Ng/0 		involves: 129X1/SvJ * C57BL/6 * C57BL/6J MGI:5477818
cn2
 		Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 		involves: 129X1/SvJ * C57BL/6J MGI:5477817


Genotype
MGI:5477818
cn1
Allelic
Composition		 Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre/ERT2)CIVE23Mlia/0
Tg(TRAMP)8247Ng/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epn1tm1.1Wami mutation (0 available); any Epn1 mutation (33 available)
Epn2tm1Ocr mutation (0 available); any Epn2 mutation (74 available)
Tg(Cdh5-cre/ERT2)CIVE23Mlia mutation (0 available)
Tg(TRAMP)8247Ng mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Reduced tumor growth in Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 Tg(TRAMP)8247Ng/0 mice

mortality/aging
increased tumor-free survival time ( J:193966 )
• tamoxifen-treated mice exhibit decreased mortality compared with Tg(TRAMP)8247Ng control mice

neoplasm
decreased tumor growth/size ( J:193966 )
• tamoxifen-treated mice develop smaller tumors compared with Tg(TRAMP)8247Ng control mice




Genotype
MGI:5477817
cn2
Allelic
Composition		 Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre/ERT2)CIVE23Mlia/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epn1tm1.1Wami mutation (0 available); any Epn1 mutation (33 available)
Epn2tm1Ocr mutation (0 available); any Epn2 mutation (74 available)
Tg(Cdh5-cre/ERT2)CIVE23Mlia mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Disrupted endothelial junctions in tumor vessels of Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 mice

mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:193966 )
• tamoxifen-treated mice transplanted with GL261glioma cells survive longer than with control mice

neoplasm
abnormal tumor vascularization ( J:193966 )
• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells exhibit disorganized, fragile, immature, enlarged and leaky tumor vessels compared with control mice
• however, treatment with a VEGFR2 kinase inhibitor restored tumor vasculature
decreased incidence of tumors by chemical induction ( J:193966 )
• tamoxifen-treated mice subjected to AOM/DSS exhibit reduced tumor incidence and decreased tumor growth compared with control mice
decreased tumor growth/size ( J:193966 )
• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells develop fewer, smaller tumors that grow at a slower rate compared with control mice
• tamoxifen-treated mice transplanted with GL261glioma cells develop smaller tumors compared with control mice
• tamoxifen-treated mice subjected to AOM/DSS exhibit reduced tumor incidence and decreased tumor growth compared with control mice

cardiovascular system
abnormal tumor vascularization ( J:193966 )
• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells exhibit disorganized, fragile, immature, enlarged and leaky tumor vessels compared with control mice
• however, treatment with a VEGFR2 kinase inhibitor restored tumor vasculature
abnormal vascular endothelial cell migration ( J:193966 )
• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated migration compared with control cells
abnormal vascular endothelial cell physiology ( J:193966 )
• endothelial cells treated with tamoxifen exhibit disrupted endothelial junctions compared with control cells
increased vascular endothelial cell proliferation ( J:193966 )
• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated proliferation compared with control cells
increased vascular permeability ( J:193966 )
• of tumor vasculature in tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells
• however, vascular permeability of blood vessels in major organs is normal

cellular
abnormal vascular endothelial cell migration ( J:193966 )
• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated migration compared with control cells
increased vascular endothelial cell proliferation ( J:193966 )
• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated proliferation compared with control cells

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:193966 )
• tamoxifen-treated mice subjected to AOM/DSS exhibit reduced tumor incidence and decreased tumor growth compared with control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory