About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxp3tm2Flv
targeted mutation 2, Richard A Flavell
MGI:3700150
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Foxp3tm2Flv/Foxp3+ involves: C57BL/6 MGI:3700541
ot2
 		Foxp3tm2Flv/Y involves: C57BL/6 MGI:3700542


Genotype
MGI:3700541
ht1
Allelic
Composition		 Foxp3tm2Flv/Foxp3+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm2Flv mutation (0 available); any Foxp3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:118631 )
• females are fertile and phenotypically normal




Genotype
MGI:3700542
ot2
Allelic
Composition		 Foxp3tm2Flv/Y
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm2Flv mutation (0 available); any Foxp3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:118631 )
• by ~3 months of age, all mice die of lymphoproliferative autoimmune syndrome

growth/size/body
decreased body size ( J:118631 )
• hemizygous mice are runted
enlarged spleen ( J:118631 )
• at death, mice have enlarged spleens

immune system
enlarged spleen ( J:118631 )
• at death, mice have enlarged spleens
abnormal immune system physiology ( J:118631 )
• infiltration of lymphocytes into non-lymphoid tissues is observed
abnormal CD4-positive, alpha-beta T cell physiology ( J:118631 )
• mutants show high levels of activated CD4+ T cells
abnormal CD8-positive, alpha-beta T cell physiology ( J:118631 )
• mutants show high levels of activated CD4+ T cells
increased autoantibody level ( J:118631 )
• serum levels are drastically elevated at death
blepharitis ( J:118631 )
• nearly all males develop eyelid defects resembling blepharitis around 4 weeks of age

hematopoietic system
enlarged spleen ( J:118631 )
• at death, mice have enlarged spleens
abnormal CD4-positive, alpha-beta T cell physiology ( J:118631 )
• mutants show high levels of activated CD4+ T cells
abnormal CD8-positive, alpha-beta T cell physiology ( J:118631 )
• mutants show high levels of activated CD4+ T cells

reproductive system
male infertility ( J:118631 )
• males are sterile (barren)

vision/eye
blepharitis ( J:118631 )
• nearly all males develop eyelid defects resembling blepharitis around 4 weeks of age

integument
scaly skin ( J:118631 )
• >50% develop scaly skin




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory