Analysis Tools
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice do not develop colitis
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• reduced numbers
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• reduced numbers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice do not develop colitis
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• reduced numbers
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• reduced numbers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal survival
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| N |
• mice exhibit normal small intestine and colon morphology
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% of mice die before weaning
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• thickened colon mucosa, ulceration, and altered vascularization
• mucosal edema in the cecum
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• reduced numbers that are not rescued by antibiotic treatment
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• enteritis with blunted and fused villi, mucosal edema, and increased cellularity of the lamina propria
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• mice exhibit shorter and thicker colons with thickened colon mucosa, ulceration, and altered vascularization compared with control mice
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• caspase-independent cell death occurs in the small intestine
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• in the colon
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• increased in the colon and cecum
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• with increased number of granulocytes, blunted and fused villi, mucosal edema, and increased cellularity of the lamina propria that are not rescued by antibiotic treatment
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• as early as 2 weeks of age, mice develop T and B cell infiltration-independent colitis with infiltration of F4/80+, Gr-1+, T, and B cells unlike co-housed Faddtm1Mpa control mice
• however, colitis is attenuated by treatment with a broad-spectrum antibiotics
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• with increased number of granulocytes, blunted and fused villi, mucosal edema, and increased cellularity of the lamina propria that are not rescued by antibiotic treatment
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• as early as 2 weeks of age, mice develop T and B cell infiltration-independent colitis with infiltration of F4/80+, Gr-1+, T, and B cells unlike co-housed Faddtm1Mpa control mice
• however, colitis is attenuated by treatment with a broad-spectrum antibiotics
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• reduced numbers that are not rescued by antibiotic treatment
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• in the colon
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• increased in the colon and cecum
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced numbers
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• reduced numbers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal circulating inflammatory cytokine levels
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| N |
• no skin lesions and normal epidermal thickness
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• spontaneous serum ALT levels are decreased compared to single Ikbkg mutants at 8 weeks of age
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• mice show increased JNK kinase activity
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• completely absent compared to single Ikbkg mutants at 8 weeks of age
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N |
• liver inflammation, hepatocyte apoptosis, increased hepatocyte proliferation, and focal lipid accumulation are inhibited in mutants compared to Ikbkg single mutants
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• completely absent compared to single Ikbkg mutants at 8 weeks of age
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• double mutants are protected from LPS-induced hepatocyte apoptosis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• peripheral T cell activation is normal
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• MOG35-55-treated mice exhibit less severe disease and reduced oligodendrocyte apoptosis compared with similarly treated wild-type mice
• however, MOG35-55-treated mice exhibit normal T cell activation
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| N |
• mice exhibit normal myelination
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• oligodendrocytes are completely resistant to TNF-induced apoptosis unlike wild-type mice
• MOG35-55-treated mice exhibit less oligodendrocyte apoptosis compared to in similarly treated wild-type mice
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• oligodendrocytes are completely resistant to TNF-induced apoptosis unlike wild-type mice
• MOG35-55-treated mice exhibit less oligodendrocyte apoptosis compared to in similarly treated wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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