Phenotypes associated with this allele

• Allele Symbol: Mtf2^Gt(XD143)Byg
• Allele Name: gene trap XD143, BayGenomics
• Allele ID: MGI:3700158
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtf2^Gt(XD143)Byg/Mtf2^Gt(XD143)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:3700543

Genotype
MGI:3700543

hm1

• Allelic Composition: Mtf2^Gt(XD143)Byg/Mtf2^Gt(XD143)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:118339 )

N • in contrast to results in the chick, no defects in left-right axis patterning (heart looping, organ position, and lung lobation) are detected

growth/size/body

abnormal incisor morphology ( J:118339 )

• in about 10% of mice

• includes misaligned incisors

misaligned incisors ( J:118339 )

decreased body weight ( J:118339 )

• adults weigh about 25% less than controls

postnatal growth retardation ( J:118339 )

• growth retardation becomes detectable by 2 weeks of age

skeleton

abnormal incisor morphology ( J:118339 )

• in about 10% of mice

• includes misaligned incisors

misaligned incisors ( J:118339 )

abnormal sternum morphology ( J:118339 )

• 4 of 25 mice display asymmetric development of the sternum

increased rib number ( J:118339 )

• mice with transformation of C7 to T1 have 14 ribs

kyphosis ( J:118339 )

• in about 10% of mice

vertebral transformation ( J:118339 )

• transformation of C7 to T1 in 6 of 25 mice

limbs/digits/tail

kinked tail ( J:118339 )

• in about 10% of mice

nervous system

hydrocephaly ( J:118339 )

• in about 10% of mice

reproductive system

decreased litter size ( J:118339 )

• average litter size for homozygous crosses is only 3.5 mice/litter compared to 8.6 mice/litter for heterozygous crosses

craniofacial

abnormal incisor morphology ( J:118339 )

• in about 10% of mice

• includes misaligned incisors

misaligned incisors ( J:118339 )