All Phenotypes Mecp2<tm2Bird> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mecp2^tm2Bird
targeted mutation 2, Adrian Bird
MGI:3700191

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mecp2^tm2Bird/Mecp2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3712286
cn2	Chat^tm2(cre)Lowl/Chat⁺ Mecp2^tm2Bird/Y	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J	MGI:6098759
cn3	Mecp2^tm2Bird/Mecp2⁺ Tg(CAG-cre/Esr1*)5Amc/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3712287
cn4	Mecp2^tm2Bird/Y Tg(CAG-cre/Esr1*)5Amc/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3832684
ot5	Mecp2^tm2Bird/Y	B6.129P2-Mecp2^tm2Bird/J	MGI:6098754
ot6	Mecp2^tm2Bird/Y	involves: 129P2/OlaHsd * C57BL/6	MGI:3712285

Allelic Composition	Mecp2^tm2Bird/Mecp2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm2Bird mutation (1 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:118365 )

• at 4 to 12 months of age, mice exhibit a progressive development of RTT-like symptoms (inertia, gait, hindlimb clasping, tremor, irregular breathing and poor general condition)

limb grasping ( J:118365 )

• at 4 to 12 months of age

tremors ( J:118365 )

• at 4 to 12 months of age

growth/size/body

obese ( J:118365 )

• mice exhibit excess weight gain

nervous system

reduced long-term potentiation ( J:118365 )

• mice develop a reduction in long term potentiation

respiratory system

abnormal breathing pattern ( J:118365 )

• at 4 to 12 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:118365

Allelic Composition	Chat^tm2(cre)Lowl/Chat⁺ Mecp2^tm2Bird/Y
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
Mecp2^tm2Bird mutation (1 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal respiration ( J:241788 )

• abnormal hypoxic breathing response

apnea ( J:241788 )

behavior/neurological

behavior/neurological phenotype ( J:241788 )

N	• mice exhibit normal activity

cardiovascular system

cardiovascular system phenotype ( J:241788 )

N	• mice exhibit a regular heart rate and show rescue of spontaneous and induced cardiac arrhythmias, long QT, and improved survival

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:241788 )

N	• mice exhibit a regular body temperature

Allelic Composition	Mecp2^tm2Bird/Mecp2⁺ Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm2Bird mutation (1 available); any Mecp2 mutation (41 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:118365 )

• at 4 to 12 months of age, mice exhibit a progressive development of RTT-like symptoms (inertia, gait, hindlimb clasping, tremor, irregular breathing and poor general condition)

• however, tamoxifen treatment after the onset of symptoms reverses symptom progression

limb grasping ( J:118365 )

• at 4 to 12 months of age

• however, tamoxifen treatment after the onset of symptoms reverses symptom progression

tremors ( J:118365 )

• at 4 to 12 months of age

• however, tamoxifen treatment after the onset of symptoms reverses symptom progression

nervous system

reduced long-term potentiation ( J:118365 )

• mice develop a reduction in long term potentiation

• however, treatment with tamoxifen returns long term potentiation to normal levels

respiratory system

abnormal breathing pattern ( J:118365 )

• at 4 to 12 months of age

• however, tamoxifen treatment after the onset of symptoms reverses symptom progression

growth/size/body

obese ( J:118365 )

• mice exhibit excess weight gain

• however, tamoxifen treatment after the onset of symptoms reverses weight gain

Allelic Composition	Mecp2^tm2Bird/Y Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm2Bird mutation (1 available); any Mecp2 mutation (41 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:118365 )

• 9 of 17 mice treated with tamoxifen at 3 to 4 weeks of age die soon after treatment

• however, tamoxifen-tocixity is not responsible for observed deaths, 8 of 17 mice treated with tamoxifen at 3 to 4 weeks of age have a normal life span, and mice treated with tamoxifen from week 12 to 17 exhibit normal lethality

behavior/neurological

behavior/neurological phenotype ( J:118365 )

N	• the surviving 8 of 17 mice treated with tamoxifen at 3 to 4 weeks of age exhibit normal behavior/neurological phenotypes

abnormal behavior ( J:118365 )

• at 12 weeks mice display low stance, inertia, tremor, arrhythmic breathing, splayed himdlimb and moderate hindlimb clasping

• during the last 4 weeks of life, mice exhibit a progressive development of RTT-like symptoms (inertia, gait, hindlimb clasping, tremor, irregular breathing and poor general condition)

• mice treated with tamoxifen at 12 to 17 weeks of age exhibit only mild RTT-like symptoms

limb grasping ( J:118365 )

• at 12 weeks, mice display moderate hindlimb clasping

• mice treated with tamoxifen at 12 to 17 weeks of age exhibit only mild RTT-like symptoms

tremors ( J:118365 )

• at 12 weeks

• mice treated with tamoxifen at 12 to 17 weeks of age exhibit only mild RTT-like symptoms

respiratory system

abnormal breathing pattern ( J:118365 )

• at 12 weeks

• mice treated with tamoxifen at 12 to 17 weeks of age exhibit only mild RTT-like symptoms

Allelic Composition	Mecp2^tm2Bird/Y
Genetic Background	B6.129P2-Mecp2^tm2Bird/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm2Bird mutation (1 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heartbeat ( J:241788 )

• irregular heart rhythm with sudden bradycardic events

abnormal heart rate ( J:241788 )

• abnormal fluctuations in heart rate in mice that die suddenly

increased heart rate variability ( J:241788 )

• increase in heart rate variability during the dark cycle

decreased heart rate ( J:241788 )

• heart rate declines dramatically to severe bradycardia before death

ventricular premature beat ( J:241788 )

• mice exhibit a higher incidence of sinus pauses and premature ventricular contractions

atrioventricular block ( J:241788 )

• an increase in sinus pauses and atrioventricular block events are seen up until 13 hours before death, but once heart rate drops to the bradycardic level, these arrhythmias cease

prolonged QT interval ( J:241788 )

increased response of heart to induced stress ( J:241788 )

• mice show increased susceptibility to induction of arrhythmias

homeostasis/metabolism

increased response of heart to induced stress ( J:241788 )

• mice show increased susceptibility to induction of arrhythmias

decreased body temperature ( J:241788 )

• decreased body temperature during both the light and dark cycle

mortality/aging

premature death ( J:241788 )

• 2 of 7 mice exhibit sudden death

• mice die prematurely with a median survival of 16 weeks

respiratory system

abnormal respiration ( J:241788 )

• abnormal hypoxic breathing response

apnea ( J:241788 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:241788

Allelic Composition	Mecp2^tm2Bird/Y
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm2Bird mutation (1 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:118365 )

• male mice survive on average 11 weeks from birth

behavior/neurological

abnormal behavior ( J:118365 )

• during the last 4 weeks of life, mice exhibit a progressive development of RTT-like symptoms (inertia, gait, hindlimb clasping, tremor, irregular breathing and poor general condition)

• at 12 weeks mice display low stance, inertia, tremor, arrhythmic breathing, splayed himdlimb and moderate hindlimb clasping

limb grasping ( J:118365 )

• at 12 weeks, mice display moderate hindlimb clasping

tremors ( J:118365 )

• at 12 weeks

respiratory system

abnormal breathing pattern ( J:118365 )

• at 12 weeks

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