Phenotypes associated with this allele

• Allele Symbol: Chrna4^tm2Jbou
• Allele Name: targeted mutation 2, Jim Boulter
• Allele ID: MGI:3700205
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrna4^tm2Jbou/Chrna4^tm2Jbou	either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)	MGI:3700261
ht2	Chrna4^tm2Jbou/Chrna4^+	either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)	MGI:3700260

Genotype
MGI:3700261

hm1

• Allelic Composition: Chrna4^tm2Jbou/Chrna4^tm2Jbou
• Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavioral arrest ( J:118273 )

• observed during seizures

seizures ( J:118273 )

• mice exhibit spontaneous recurrent seizures, ranging from 1-5s of behavioral arrest to extended (2-60 seconds) of rhythmic jerking movements of extremities, with loss of balance and falling over

clonic seizures ( J:118273 )

nervous system

abnormal nervous system physiology ( J:118273 )

seizures ( J:118273 )

• mice exhibit spontaneous recurrent seizures, ranging from 1-5s of behavioral arrest to extended (2-60 seconds) of rhythmic jerking movements of extremities, with loss of balance and falling over

clonic seizures ( J:118273 )

abnormal brain wave pattern ( J:118273 )

• mutants show abnormal EEG activity during seizure episodes, such as repetitive discharges with paroxysmal onset and sudden termination with asymmetric rhythm patterns; this is observed for 5.7% of a 4-hour recording period

Genotype
MGI:3700260

ht2

• Allelic Composition: Chrna4^tm2Jbou/Chrna4⁺
• Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

behavior/neurological

behavioral arrest ( J:118273 )

• observed during seizures

seizures ( J:118273 )

• mice exhibit spontaneous recurrent seizures, ranging from 1-5s of behavioral arrest to extended (2-60 seconds) of rhythmic jerking movements of extremities, with loss of balance and falling over

clonic seizures ( J:118273 )

nervous system

abnormal nervous system physiology ( J:118273 )

seizures ( J:118273 )

• mice exhibit spontaneous recurrent seizures, ranging from 1-5s of behavioral arrest to extended (2-60 seconds) of rhythmic jerking movements of extremities, with loss of balance and falling over

clonic seizures ( J:118273 )

abnormal brain wave pattern ( J:118273 )

• mutants show abnormal EEG activity during seizure episodes, such as repetitive discharges with paroxysmal onset and sudden termination with asymmetric rhythm patterns; this is observed for 5.1% of a 4-hour recording period