Phenotypes associated with this allele

• Allele Symbol: Dlg4^tm1Rlh
• Allele Name: targeted mutation 1, Richard L Huganir
• Allele ID: MGI:3700207
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dlg4^tm1Rlh/Dlg4^tm1Rlh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3700390

Genotype
MGI:3700390

hm1

• Allelic Composition: Dlg4^tm1Rlh/Dlg4^tm1Rlh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal innervation ( J:118286 )

• small but significant increase in spine length in synapses from the CA1 region of the hippocampus; however, overall spine volume is not significantly different from controls

abnormal glutamate-mediated receptor currents ( J:118286 )

• evoked EPSCs in cells clamped at +40 mV indicate a significant reduction in the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor to N-methyl-D-aspartate receptor (AMPAR/NMDAR) ratio

abnormal AMPA-mediated synaptic currents ( J:118286 )

• 2-photon uncaging in single synapses from the CA1 region of the hypocampus reveals more synapses with very low or zero AMPA/NMDA (silent synapses)

• silent synapses are only readily detected in homozygous mice and their presence does not correlate to spine volume

abnormal NMDA-mediated synaptic currents ( J:118286 )

• slower decay kinetics in the NMDA-mediated synaptic currents in synapses from the CA1 region of the hippocampus

enhanced long-term potentiation ( J:118286 )

• increase in the magnitude of theta-burst-induced LTP in the CA1 region of the hippocampus