Phenotypes associated with this allele

• Allele Symbol: Celf1^tm1Cba
• Allele Name: targeted mutation 1, Charles Babinet
• Allele ID: MGI:3700209
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Celf1^tm1Cba/Celf1^tm1Cba	involves: 129S2/SvPas * C57BL/6	MGI:3700246

Genotype
MGI:3700246

hm1

• Allelic Composition: Celf1^tm1Cba/Celf1^tm1Cba
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:118291 )

• at 8-10 days postnatal, proportion of homozygous pups is significantly decreased from expected frequency, while at E18.5 and at birth, proportion conforms to expected frequency

• deaths of some mutants are observed at 1-2 days postnatal

embryo

decreased placenta weight ( J:118291 )

• weight of placentas of homozygous conceptuses weigh less than those of heterozygotes

growth/size/body

decreased body size ( J:118291 )

• homozygotes are smaller than littermates at 1 and 10 days after birth

• body and organ weights of adult mutants are ~65% that of littermates

slow postnatal weight gain ( J:118291 )

• rate of weight gain of male and female mice is less than that observed for littermates; at 14 weeks, male weighs 23% less than littermates, and female weighs 16% less

• body and organ weights of adult mutants are ~65% that of littermates

fetal growth retardation ( J:118291 )

• growth deficiency is apparent before birth, with homozygous E18.5 embryos 18% smaller than heterozygotes

reproductive system

arrest of spermatogenesis ( J:118291 )

♂ • in more than 60% of testes examined, seminiferous tubules are devoid of elongated spermatids and spermatozoa

♂ • in some males, arrest of spermatogenesis occurrs at step 7 of spermiogenesis, before spermatid elongation begins

reduced female fertility ( J:118291 )

♀ • female mice mated with heterozygous or wild-type males produced only 1 litter during a 3 month period

decreased litter size ( J:118291 )

male infertility ( J:118291 )

♂ • males lacking elongated spermatids in seminiferous tubules (3/3 males) or having only few elongated spermatids (2/4 males) are sterile

reduced male fertility ( J:118291 )

♂ • fertility of males is dramatically reduced; very few litters were produced during matings with heterozygous or wild-type females