All Phenotypes Trpm4<tm1.1Mfre> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trpm4^tm1.1Mfre
targeted mutation 1.1, Marc Freichel
MGI:3700529

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpm4^tm1.1Mfre/Trpm4^tm1.1Mfre	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ	MGI:3700952

Allelic Composition	Trpm4^tm1.1Mfre/Trpm4^tm1.1Mfre
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm4^tm1.1Mfre mutation (0 available); any Trpm4 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to type I hypersensitivity reaction ( J:118679 )

• mutant mice show an enhanced acute anaphylaxis in the skin (passive cutaneous anaphylaxis, PCA) to treatment with conjugated human serum albumin (DNP-HAS)

cardiovascular system

increased vascular permeability ( J:118679 )

• extravasation of dye into the skin is enhanced after exposure to DNP-HSA

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:118679 )

• mutant bone marrow-derived mast cells show greater calcium influx upon IgE-receptor stimulation than wild-type mast cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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