Phenotypes associated with this allele

• Allele Symbol: Rag2^tm1Libo
• Allele Name: targeted mutation 1, Lisa Borghesi
• Allele ID: MGI:3700748
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rag2^tm1Libo/Rag2^tm1Libo	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:3712280

Genotype
MGI:3712280

hm1

• Allelic Composition: Rag2^tm1Libo/Rag2^tm1Libo
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:84563 )

decreased bone marrow cell number ( J:84563 )

• IgM+ cells are reduced (15% compared to 29% in wild-type)

• B220+ cells are decreased by 2.5-fold, pre-B cells by 3-fold and IgM+ B cells by 3-fold compared to wild-type

• however, pro-B cell numbers are equivalent to wild-type

decreased B cell number ( J:84563 )

• the percentage of B220+ cells in the spleen is decreased

decreased pre-B cell number ( J:84563 )

• cell number is decreased (15.6% compared to 37.5% in wild-type)

decreased monocyte cell number ( J:84563 )

• splenocytes numbers are decreased

abnormal B cell physiology ( J:84563 )

• V(D)J recombinase activity is diminished

immune system

abnormal B cell differentiation ( J:84563 )

decreased B cell number ( J:84563 )

• the percentage of B220+ cells in the spleen is decreased

decreased pre-B cell number ( J:84563 )

• cell number is decreased (15.6% compared to 37.5% in wild-type)

decreased monocyte cell number ( J:84563 )

• splenocytes numbers are decreased

abnormal B cell physiology ( J:84563 )

• V(D)J recombinase activity is diminished