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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ltb4r1tm1Tksh
targeted mutation 1, Takao Schimizu
MGI:3701260
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ltb4r1tm1Tksh/Ltb4r1tm1Tksh B6.Cg-Ltb4r1tm1Tksh MGI:3701834
hm2
 		Ltb4r1tm1Tksh/Ltb4r1tm1Tksh C.Cg-Ltb4r1tm1Tksh MGI:5517542
hm3
 		Ltb4r1tm1Tksh/Ltb4r1tm1Tksh involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:5517543


Genotype
MGI:3701834
hm1
Allelic
Composition		 Ltb4r1tm1Tksh/Ltb4r1tm1Tksh
Genetic
Background		 B6.Cg-Ltb4r1tm1Tksh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb4r1tm1Tksh mutation (2 available); any Ltb4r1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased eosinophil cell number ( J:118995 )
• broncheoalveolar lavage fluid (BALF) from mutants has lower eosinophil recruitment compared to wild-type after OVA challenge
decreased IgE level ( J:118995 )
• in mutants challenged with OVA, total IgE in BALF and plasma is lower than in wild-type
decreased susceptibility to type I hypersensitivity reaction ( J:197334 )
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit decreased dye extravasation (a measure of edema) compared with wild-type mice
abnormal cytokine secretion ( J:118995 )
• increase in Il-5 and Il-13 after OVA challenge is reduced in mutants; leukotriene B4 (Ltb4) increase is absent in OVA challenged mutants
• peribronchial lymph node cells from mutants show decreased Il-5 and Il-13 production in vitro after restimulation with OVA compared to wild-type cellsJ118995Ltb4r
lung inflammation ( J:118995 )
• peribronchial and perivascular accumulation of inflammatory cells, and changes to integrity of the airway walls is significantly decreased in mutants compared to wild-type after OVA challenge

hematopoietic system
decreased eosinophil cell number ( J:118995 )
• broncheoalveolar lavage fluid (BALF) from mutants has lower eosinophil recruitment compared to wild-type after OVA challenge
decreased IgE level ( J:118995 )
• in mutants challenged with OVA, total IgE in BALF and plasma is lower than in wild-type

respiratory system
abnormal respiratory system physiology ( J:118995 )
• goblet cells in airway epithelium produce significantly more mucous than wild-type cells after OVA challenge
lung inflammation ( J:118995 )
• peribronchial and perivascular accumulation of inflammatory cells, and changes to integrity of the airway walls is significantly decreased in mutants compared to wild-type after OVA challenge
decreased airway responsiveness ( J:118995 )
• after ovalbumin (OVA) challenge and methacholine treatment in OVA-sensitized mice, airway hyperresponsiveness is attenuated in mutants compared to wild-type

cellular
decreased cell proliferation ( J:118995 )
• peribronchial lymph node cells from mutants show attenuated proliferation in vitro after restimulation with OVA

homeostasis/metabolism
edema ( J:197334 )
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit decreased dye extravasation (a measure of edema) compared with wild-type mice
abnormal hormone level ( J:118995 )
• erythropoietin activity in mutant lung homogenates is reduced after OVA challenge compared to controls




Genotype
MGI:5517542
hm2
Allelic
Composition		 Ltb4r1tm1Tksh/Ltb4r1tm1Tksh
Genetic
Background		 C.Cg-Ltb4r1tm1Tksh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb4r1tm1Tksh mutation (2 available); any Ltb4r1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:133998 )
• bone marrow-derived mast cells fail to migrate in response to LTB4 unlike wild-type cells
• however, bone marrow-derived mast cells exhibit normal migration in response to 12-12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid (12-HHT) and stem cell factor (SCF)

hematopoietic system
abnormal mast cell physiology ( J:133998 )
• bone marrow-derived mast cells fail to migrate in response to LTB4 unlike wild-type cells
• however, bone marrow-derived mast cells exhibit normal migration in response to 12-12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid (12-HHT) and stem cell factor (SCF)




Genotype
MGI:5517543
hm3
Allelic
Composition		 Ltb4r1tm1Tksh/Ltb4r1tm1Tksh
Genetic
Background		 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb4r1tm1Tksh mutation (2 available); any Ltb4r1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal granulocyte physiology ( J:118995 )
• impaired degranulation

hematopoietic system
abnormal granulocyte physiology ( J:118995 )
• impaired degranulation




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory