Phenotypes associated with this allele

• Allele Symbol: Eloa^tm1Aso
• Allele Name: targeted mutation 1, T Aso
• Allele ID: MGI:3701319
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eloa^tm1Aso/Eloa^tm1Aso	involves: 129S/SvEv * C57BL/6	MGI:3704883
cx2	Eloa^tm1Aso/Eloa^tm1Aso Trp53^tm1Sia/Trp53^tm1Sia	involves: 129S/SvEv * C57BL/6 * CBA	MGI:3704887

Genotype
MGI:3704883

hm1

• Allelic Composition: Eloa^tm1Aso/Eloa^tm1Aso
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119126 )

• died at between 10.5 and 12.5 of gestation

embryo

increased embryonic tissue cell apoptosis ( J:119126 )

• in live E10.5 embryos

embryonic growth retardation ( J:119126 )

• in live E10.5 embryos

decreased embryo size ( J:119126 )

• in live E10.5 embryos

abnormal embryonic neuroepithelium morphology ( J:119126 )

• the cellularity of the spinal and cranial neuroepithelium was significantly reduced in live E10.5 embryos

decreased embryonic neuroepithelium thickness ( J:119126 )

• the thickness of the spinal and cranial neuroepithelium was significantly reduced in live E10.5 embryos

growth/size/body

embryonic growth retardation ( J:119126 )

• in live E10.5 embryos

decreased embryo size ( J:119126 )

• in live E10.5 embryos

nervous system

abnormal embryonic neuroepithelium morphology ( J:119126 )

• the cellularity of the spinal and cranial neuroepithelium was significantly reduced in live E10.5 embryos

decreased embryonic neuroepithelium thickness ( J:119126 )

• the thickness of the spinal and cranial neuroepithelium was significantly reduced in live E10.5 embryos

delayed brain development ( J:119126 )

• a poor development of the central nervous system and liver

liver/biliary system

delayed hepatic development ( J:119126 )

• liver in live E10.5 embryos were markedly decreased in size and composed of irregular trabeculae with fewer hepatocytes

cardiovascular system

heart hypoplasia ( J:119126 )

• in live E10.5 embryos

thin ventricular wall ( J:119126 )

• showing minimum thickness of one cell layer in live E10.5 embryos

cellular

increased embryonic tissue cell apoptosis ( J:119126 )

• in live E10.5 embryos

increased fibroblast apoptosis ( J:119126 )

• in MEF prepared from mutant embryos

decreased cell proliferation ( J:119126 )

• in MEF prepared from mutant embryos

early cellular replicative senescence ( J:119126 )

• in MEF prepared from mutant embryos

integument

pallor ( J:119126 )

• live E10.5 embryos were strikingly paler than control

Genotype
MGI:3704887

cx2

• Allelic Composition: Eloa^tm1Aso/Eloa^tm1Aso; Trp53^tm1Sia/Trp53^tm1Sia
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119126 )

• died at between 10.5 and 12.5 of gestation

• similar to phenotype found in Tceb3^tm1Aso homozygous embryos

embryo

increased embryonic tissue cell apoptosis ( J:119126 )

• in live E10.5 embryos

• similar to phenotype found in Tceb3^tm1Aso homozygous embryos

embryonic growth retardation ( J:119126 )

• in live E10.5 embryos

• morphologically not distinguishable from Tceb3^tm1Aso homozygous embryos

growth/size/body

embryonic growth retardation ( J:119126 )

• in live E10.5 embryos

• morphologically not distinguishable from Tceb3^tm1Aso homozygous embryos

cellular

increased embryonic tissue cell apoptosis ( J:119126 )

• in live E10.5 embryos

• similar to phenotype found in Tceb3^tm1Aso homozygous embryos