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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Crmp1tm1Pako
targeted mutation 1, Pappachan Kolattukudy
MGI:3701338
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Crmp1tm1Pako/Crmp1tm1Pako involves: 129/Sv * ICR MGI:3703436
cx2
 		Crmp1tm1Pako/Crmp1tm1Pako
Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh
Tg(Thy1-YFP)HJrs/0 		involves: 129 * C57BL/6J * CBA * FVB/N MGI:5312896
cx3
 		Crmp1tm1Pako/Crmp1tm1Pako
Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh 		involves: 129 * C57BL/6J * FVB/N MGI:5312895
cx4
 		Crmp1tm1Pako/Crmp1tm1Pako
Dab1yot/Dab1+ 		involves: 129/Sv * ICR MGI:3703439


Genotype
MGI:3703436
hm1
Allelic
Composition		 Crmp1tm1Pako/Crmp1tm1Pako
Genetic
Background		 involves: 129/Sv * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crmp1tm1Pako mutation (2 available); any Crmp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:119127 )
N
• no behavioral alterations were observed
• no gross anatomical changes in brain

nervous system
abnormal neuronal migration ( J:116689 , J:119127 )
• radial migration of cortical neurons was retarded in P10 mutant mice in vivo by BrdU birth dating analysis (J:116689)
• a 20% decrease in the number of granule cells migrating out of explants from P8 cerebellum (J:119127)
• granule cel migration is not significantly modified in developing brain of P12 mutant mice in vivo (J:119127)
abnormal neuronal precursor proliferation ( J:119127 )
• at P5, decreased proliferation and apoptosis of granule cells in the external granular layer of cerebellum

cellular
abnormal neuronal migration ( J:116689 , J:119127 )
• radial migration of cortical neurons was retarded in P10 mutant mice in vivo by BrdU birth dating analysis (J:116689)
• a 20% decrease in the number of granule cells migrating out of explants from P8 cerebellum (J:119127)
• granule cel migration is not significantly modified in developing brain of P12 mutant mice in vivo (J:119127)
abnormal neuronal precursor proliferation ( J:119127 )
• at P5, decreased proliferation and apoptosis of granule cells in the external granular layer of cerebellum




Genotype
MGI:5312896
cx2
Allelic
Composition		 Crmp1tm1Pako/Crmp1tm1Pako
Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh
Tg(Thy1-YFP)HJrs/0
Genetic
Background		 involves: 129 * C57BL/6J * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crmp1tm1Pako mutation (2 available); any Crmp1 mutation (45 available)
Dpysl2tm1.1Gosh mutation (0 available); any Dpysl2 mutation (34 available)
Tg(Thy1-YFP)HJrs mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex pyramidal cell morphology ( J:180581 )
• the basal dendrites of layer V pyramidal neurons grow to the apical side with curling and collaterals from apical trunks show disorientation and winding
abnormal dendrite morphology ( J:180581 )
• the basal dendrites of layer V pyramidal neurons grow to the apical side with curling and collaterals from apical trunks show disorientation and winding
• cortical neurons show an increase in the number of primary dendrites
• the highest number of dendrite crossings is found at about 40 um compared to 60-80 um in controls
• the basal dendritic field is further shifted to the apical part of the cell body and to the close part of cell body compared to mutant mice wild-type for Crmp1




Genotype
MGI:5312895
cx3
Allelic
Composition		 Crmp1tm1Pako/Crmp1tm1Pako
Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crmp1tm1Pako mutation (2 available); any Crmp1 mutation (45 available)
Dpysl2tm1.1Gosh mutation (0 available); any Dpysl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:180581 )
N
• gross cytoarchitecture of the cortical layer is essentially normal
abnormal dendrite morphology ( J:180581 )
• significant increase in the number of primary neurons displaying irregular curling dendritic elongation in culture




Genotype
MGI:3703439
cx4
Allelic
Composition		 Crmp1tm1Pako/Crmp1tm1Pako
Dab1yot/Dab1+
Genetic
Background		 involves: 129/Sv * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crmp1tm1Pako mutation (2 available); any Crmp1 mutation (45 available)
Dab1yot mutation (1 available); any Dab1 mutation (77 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampus layer morphology ( J:116689 )
• disrupted hippocampal lamination revealed by Nissl staining in P10 mutant brain




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory