Phenotypes associated with this allele

• Allele Symbol: Wnt9a^tm1.1Chha
• Allele Name: targeted mutation 1.1, Christine Hartmann
• Allele ID: MGI:3701349
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt9a^tm1.1Chha/Wnt9a^tm1.1Chha	involves: 129X1/SvJ * C57BL/6J * SJL/J	MGI:3703329

Genotype
MGI:3703329

hm1

• Allelic Composition: Wnt9a^tm1.1Chha/Wnt9a^tm1.1Chha
• Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:119030 )

• died within 12 hours of birth

• no obvious abnormalities in major organs

skeleton

abnormal cranium morphology ( J:119030 )

• the cartilaginous base was extended dorsally, esp. at the base of parietal bones

abnormal basioccipital bone morphology ( J:119030 )

• the basioccipital bone was abnormally shaped and reduced in size

small basioccipital bone ( J:119030 )

abnormal frontal bone morphology ( J:119030 )

• the frontal bone plates were further apart from each other

abnormal interfrontal bone morphology ( J:119030 )

• ectopic cartilaginous material was present in the interfrontal region

abnormal supraoccipital bone morphology ( J:119030 )

• the supraoccipital bone showed reduced mineralization

hyoid bone hypoplasia ( J:119030 )

decreased length of long bones ( J:119030 )

• slightly reduced appendicular long bones particularly in the mineralized region

abnormal cervical atlas morphology ( J:119030 )

• hypoplastic

ectopic cartilage ( J:119030 )

• ectopic cartilaginous material in the interfrontal and sagittal suture regions and in the elbow joint

abnormal joint morphology ( J:119030 )

• ectopic cartilaginous material in the interfrontal and sagittal suture regions and in the elbow joint

• synovial chondroid metaplasia

• partial joint fusions in tarsal and carpal elements

• no gross joint defects

abnormal sagittal suture morphology ( J:119030 )

• ectopic cartilage nodules were present within the midline sutures

fused joints ( J:119030 )

• partial joint fusions in tarsal and carpal elements

abnormal skeleton development ( J:119030 )

• an ectopic Alcian Blue-positive nodule in the elbow region

abnormal chondrocyte physiology ( J:119030 )

• altered chondrocyte maturation

craniofacial

abnormal cranium morphology ( J:119030 )

• the cartilaginous base was extended dorsally, esp. at the base of parietal bones

abnormal sagittal suture morphology ( J:119030 )

• ectopic cartilage nodules were present within the midline sutures

abnormal basioccipital bone morphology ( J:119030 )

• the basioccipital bone was abnormally shaped and reduced in size

small basioccipital bone ( J:119030 )

abnormal frontal bone morphology ( J:119030 )

• the frontal bone plates were further apart from each other

abnormal interfrontal bone morphology ( J:119030 )

• ectopic cartilaginous material was present in the interfrontal region

abnormal supraoccipital bone morphology ( J:119030 )

• the supraoccipital bone showed reduced mineralization

hyoid bone hypoplasia ( J:119030 )