All Phenotypes Wnt9a<tm2Chha> MGI Mouse

neonatal lethality, complete penetrance ( J:119030 )

• died within 12 hours of birth

• no obvious abnormalities in major organs

abnormal cranium morphology ( J:119030 )

• the cartilaginous base was extended dorsally, esp. at the base of parietal bones

abnormal basioccipital bone morphology ( J:119030 )

• the basioccipital bone was abnormally shaped and reduced in size

small basioccipital bone ( J:119030 )

abnormal frontal bone morphology ( J:119030 )

• the frontal bone plates were further apart from each other

abnormal interfrontal bone morphology ( J:119030 )

• ectopic cartilaginous material was present in the interfrontal region

abnormal supraoccipital bone morphology ( J:119030 )

• the supraoccipital bone showed reduced mineralization

hyoid bone hypoplasia ( J:119030 )

decreased length of long bones ( J:119030 )

• slightly reduced appendicular long bones particularly in the mineralized region

abnormal cervical atlas morphology ( J:119030 )

• hypoplastic

ectopic cartilage ( J:119030 )

• ectopic cartilaginous material in the interfrontal and sagittal suture regions and in the elbow joint

abnormal joint morphology ( J:119030 )

• ectopic cartilaginous material in the interfrontal and sagittal suture regions and in the elbow joint

• synovial chondroid metaplasia

• partial joint fusions in tarsal and carpal elements

• no gross joint defects

abnormal sagittal suture morphology ( J:119030 )

• ectopic cartilage nodules were present within the midline sutures

fused joints ( J:119030 )