Analysis Tools
mortality/aging
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• fail to thrive and die within 1 week of birth
• however, unlike Sox10 null mice no embryonic or perinatal lethality is seen
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growth/size/body
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• severe
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nervous system
| N |
• at E10.5 cranial ganglia are all present and appear normal
• at E12.5 both gliogenesis and neurogenesis occur normally in dorsal root ganglia
• development of Schwann cells in the peripheral nerves is normal
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• few if any melanoblasts are present at E12.5
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• at E18.5 both the small and large intestines lack enteric neurons and enteric neuronal precursors
• however, the esophagus and stomach have normal appearing entric ganglia and plexus
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• sympathetic ganglia appear slightly smaller and contain fewer Phox2b+ cells
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• very few maturing oligodendrocytes are present at E18.5 in the white matter of the spinal cord
• the number of myelinating oligodendrocytes in the white matter of the spinal cord is decreased at P7
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pigmentation
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• absence of melanin from all hair follicles
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embryo
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• increased apoptosis is seen in the area where vagal neural crest cells are found prior to gut colonization
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• enteric neural crest cells fail to colonize the fore- and hindgut
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• few if any melanoblasts are present at E12.5
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integument
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• absence of melanin from all hair follicles
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cellular
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• increased apoptosis is seen in the area where vagal neural crest cells are found prior to gut colonization
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• enteric neural crest cells fail to colonize the fore- and hindgut
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