Phenotypes associated with this allele

• Allele Symbol: Igh-V^{tm1(Igh-Vx24)Hmb}
• Allele Name: targeted mutation 1, Dan Holmberg
• Allele ID: MGI:3701360
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh-V^tm1(Igh-Vx24)Hmb/Igh-V^tm1(Igh-Vx24)Hmb	involves: 129/Sv * C57BL/6	MGI:3701773

Genotype
MGI:3701773

hm1

• Allelic Composition: Igh-V^{tm1(Igh-Vx24)Hmb}/Igh-V^{tm1(Igh-Vx24)Hmb}
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lymphoma incidence ( J:54380 )

• 71% of F1 progeny develop lymphomas before 30 weeks of age

• when F1 mice are backcrossed to C57BL/6, 46% of offspring develop lymphomas between 11 and 35 weeks of age

• tumors from affected mice involve spleen, lymph nodes, thymus, bone marrow, liver and often kidneys or lungs; tumors are lymphblastic with proliferation of monotonous medium-sized cells with nucleoli

increased T cell derived lymphoma incidence ( J:54380 )

• all tumors analyzed express alpha, beta TCR and lack expression of B cell markers B220 and sIg

• in transplant experiments, syngeneic reciepients of tumor cells develop T cell lymphomas within 14 days

cellular

increased apoptosis ( J:54380 )

• tumors show a high rate of cell death

increased cell proliferation ( J:54380 )

• tumors show high mitotic indices with S-phase fractions between 25 and 35%

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:54380 )

• all tumors analyzed express alpha, beta TCR and lack expression of B cell markers B220 and sIg

• in transplant experiments, syngeneic reciepients of tumor cells develop T cell lymphomas within 14 days

immune system

increased T cell derived lymphoma incidence ( J:54380 )

• all tumors analyzed express alpha, beta TCR and lack expression of B cell markers B220 and sIg

• in transplant experiments, syngeneic reciepients of tumor cells develop T cell lymphomas within 14 days

hematopoietic system

increased T cell derived lymphoma incidence ( J:54380 )

• all tumors analyzed express alpha, beta TCR and lack expression of B cell markers B220 and sIg

• in transplant experiments, syngeneic reciepients of tumor cells develop T cell lymphomas within 14 days