Phenotypes associated with this allele

• Allele Symbol: Nmur2^m1Hzg
• Allele Name: mutation 1, Hongkui Zheng
• Allele ID: MGI:3701426
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nmur2^m1Hzg/Nmur2^m1Hzg	involves: 129/Sv * 129S1/SvImJ * C57BL/6	MGI:3701788

Genotype
MGI:3701788

hm1

• Allelic Composition: Nmur2^m1Hzg/Nmur2^m1Hzg
• Genetic Background: involves: 129/Sv * 129S1/SvImJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal food intake ( J:117649 )

• administration of neuromedin had no apparent effect on overnight food intake in mutants whereas controls show decreased food intake and a trend toward a weight reduction after treatment

decreased compensatory feeding amount ( J:117649 )

• mutants show a slight, but significant decrease in food intake relative to wild-type at 4 and 24 hours postfast

decreased grooming behavior ( J:117649 )

• mutants do not display grooming behavior upon central injection of neuromedin U in contrast to treated wild-type mice which show intense grooming behavior

abnormal pain threshold ( J:117649 )

• following centrally injected neuromedin U, mutants show no hyperalgesic effect to formalin injection, while wild-type mice show a prolonged hyperalgesic response

increased thermal nociceptive threshold ( J:117649 )

• mutants show a mild but consistent increased latency of hindlimb shaking/paw licking response in hot plate test

nervous system

nervous system phenotype ( J:117649 )

N • mutants do not display obvious differences in electrophysiological properties compared to wild-type