Phenotypes associated with this allele

• Allele Symbol: Del(16Zfp520-Slc25a1)1Awb
• Allele Name: deletion, chr 16, Anthony Wynshaw-Boris 1
• Allele ID: MGI:3701447
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Del(16Zfp520-Slc25a1)1Awb/+	B6.129S6-Del(16Zfp520-Slc25a1)1Awb	MGI:5451008
ht2	Del(16Zfp520-Slc25a1)1Awb/+	involves: 129S6/SvEvTac	MGI:3701781
ht3	Del(16Zfp520-Slc25a1)1Awb/+	involves: 129S6/SvEvTac * NIH Black Swiss	MGI:3701780

Genotype
MGI:5451008

ht1

• Allelic Composition: Del(16Zfp520-Slc25a1)1Awb/+
• Genetic Background: B6.129S6-Del(16Zfp520-Slc25a1)1Awb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:190908 )

N • no change in long term potentiation is detected

Genotype
MGI:3701781

ht2

• Allelic Composition: Del(16Zfp520-Slc25a1)1Awb/+
• Genetic Background: involves: 129S6/SvEvTac

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:58432 )

• no homozygous mutants are born; between E5.5 and E7.5, normal-appearing embryos and empty deciduae are found, suggesting early post-implantation homozygous lethality

embryo

inner cell mass degeneration ( J:58432 )

• inner cell mass cells of homozygous blastocysts often do not hatch after 4 days and degenerate soon afterwards

nervous system

abnormal prepulse inhibition ( J:58432 )

• prepulse inhibition response is abnormal in heterozygous mice; percent inhibition is significantly higher than in controls

• Background Sensitivity: levels of prepulse inhibition are higher at the 2 highest prepulse sound levels than on mixed 129S6/Black Swiss) background

behavior/neurological

behavior/neurological phenotype ( J:58432 )

N

cardiovascular system

cardiovascular system phenotype ( J:58432 )

N • mutants do not show abnormal development of cardiovascular system and do not show signs of DiGeorge Syndrome or VCS

Genotype
MGI:3701780

ht3

• Allelic Composition: Del(16Zfp520-Slc25a1)1Awb/+
• Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:58432 )

• no homozygous mutants are born; between E5.5 and E7.5, normal-appearing embryos and empty deciduae are found, suggesting early post-implantation homozygous lethality

embryo

inner cell mass degeneration ( J:58432 )

• inner cell mass cells of homozygous blastocysts often do not hatch after 4 days and degenerate soon afterwards

nervous system

abnormal prepulse inhibition ( J:58432 )

• prepulse inhibition response is abnormal in heterozygous mice; percent inhibition is significantly higher than in controls

• Background Sensitivity: levels of prepulse inhibition are lower at the 2 highest prepulse sound levels than on inbred 129S6/SvEvTac background

behavior/neurological

behavior/neurological phenotype ( J:58432 )

N • open field behaviors, acoustic startle responses, contextual and cued fear responses are similar in mutants and wild-type

impaired coordination ( J:58432 )

• male mice perform more poorly compared than wild-type mice in the rotarod test

cardiovascular system

cardiovascular system phenotype ( J:58432 )

N • mutants do not show abnormal development of cardiovascular system and do not show signs of DiGeorge Syndrome or VCS