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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ticam1tm1Tsse
targeted mutation 1, Tsukasa Seya
MGI:3701472
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ticam1tm1Tsse/Ticam1tm1Tsse B6.129-Ticam1tm1Tsse MGI:3703444
cx2
 		Ticam1tm1Tsse/Ticam1tm1Tsse
Tg(PVR)1Kkst/0 		involves: 129 * C57BL/6 * ICR MGI:5558901


Genotype
MGI:3703444
hm1
Allelic
Composition		 Ticam1tm1Tsse/Ticam1tm1Tsse
Genetic
Background		 B6.129-Ticam1tm1Tsse
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ticam1tm1Tsse mutation (0 available); any Ticam1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:118750 )
• natural killer cells from polyI:C-treated mice do not display cytotoxicity towards B16 melanoma cells

neoplasm
increased tumor growth/size ( J:118750 )
• in mice treated with polyI:C the reduction in tumor growth of injected B16 melanoma cells is less than in polyI:C treated control mice

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:118750 )
• natural killer cells from polyI:C-treated mice do not display cytotoxicity towards B16 melanoma cells




Genotype
MGI:5558901
cx2
Allelic
Composition		 Ticam1tm1Tsse/Ticam1tm1Tsse
Tg(PVR)1Kkst/0
Genetic
Background		 involves: 129 * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(PVR)1Kkst mutation (0 available)
Ticam1tm1Tsse mutation (0 available); any Ticam1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:179625 )
• in polivirus-infected mice at low doses
• however, high doses provides the same lethality as in Tg(PVR)1Kkst mice

immune system
abnormal interferon-alpha secretion ( J:179625 )
• following injection of high poliovirus titers, mice fail to exhibit an increase in serum IFN-alpha Tg(PVR)1Kkst mice
increased susceptibility to Picornaviridae infection ( J:179625 )
• mice infected with low doses of poliovirus exhibit increased organ titers, reduced lethality and fail to exhibit an increase in IFN-alpha serum levels compared with Tg(PVR)1Kkst mice
• mouse embryonic fibroblasts are more susceptible to poliovirus-induced cell death compared with cells from Tg(PVR)1Kkst mice
increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:179625 )
• in polivirus-infected mice at low doses
• however, high doses provides the same lethality as in Tg(PVR)1Kkst mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory